Document 0015
 DOCN  M9460015
 TI    Levels of T-lymphocyte subpopulations, interleukin-1 beta, and soluble
       interleukin-2 receptor in acute myocardial infarction.
 DT    9408
 AU    Blum A; Sclarovsky S; Rehavia E; Shohat B; Cardiovascular Division,
       Beilinson Medical Center, Petah Tiqva,; Israel.
 SO    Am Heart J. 1994 May;127(5):1226-30. Unique Identifier : AIDSLINE
       MED/94226010
 AB    T-lymphocyte levels may adversely affect the clinical course and outcome
       of patients with acute myocardial infarction (AMI). To characterize the
       T-lymphocyte profile during AMI and to explore whether these cells play
       a detrimental role in the extent of myocardial insult, levels of
       T-lymphocyte subpopulations, free soluble interleukin-2 receptor
       (sIL-2R), and interleukin-1 beta (IL-1 beta), were measured during the
       first week of AMI. Results were correlated with left ventricular
       ejection fraction (LVEF), age, sex, survival rate, thrombolytic therapy,
       and the occurrence of reinfarction. Thirty-nine patients, 20 men and 19
       women aged 30 to 80 years, with first AMI were included. Patients were
       divided into two groups. Group A (13 patients) experienced reinfarction;
       group B (26 patients) did not. T-helper and-suppressor cells were
       measured by the indirect immunofluorescence method and sIL-2R and IL-1
       serum levels by enzyme-linked immunosorbent assay (ELISA) methods on
       days 1, 4, and 7 after AMI. A low count of T-helper cells (CD4) was
       found on the first day after AMI in both AMI groups; however, the count
       returned to normal in group B but not in group A. A significant
       correlation (r = 0.63) was found between T-helper cell count on day 4 of
       AMI and LVEF assessed by radionuclide ventriculography, and between the
       CD4/CD8 ratio on day 1 and the creatine phosphokinase level (r =
       -0.6950). High sIL-2R levels were found in groups A and B of the AMI
       patients as compared with the control group (p < or = 0.05).(ABSTRACT
       TRUNCATED AT 250 WORDS)
 DE    Adult  Aged  Aged, 80 and over  Comparative Study  CD4-CD8 Ratio  Female
       Human  Interleukin-1/*BLOOD  Leukocyte Count  Male  Middle Age
       Myocardial Infarction/*IMMUNOLOGY/MORTALITY/PHYSIOPATHOLOGY  Receptors,
       Interleukin-2/*ANALYSIS  Recurrence  Solubility  Stroke Volume
       T-Lymphocyte Subsets/*IMMUNOLOGY  Time Factors  JOURNAL ARTICLE

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