Document 0019
 DOCN  M9460019
 TI    Acute hypersplenism and thrombocytopenia: a new presentation of
       disseminated mycobacterial infection in patients with acquired
       immunodeficiency syndrome.
 DT    9408
 AU    Levin M; Sanford R. Nalitt Center for Cancer and Blood-Related
       Diseases,; Staten Island University Hospital, N.Y. 10305.
 SO    Acta Haematol. 1994;91(1):28-31. Unique Identifier : AIDSLINE
       MED/94225886
 AB    We describe 2 patients with acquired immunodeficiency syndrome who
       presented with acute or subacute splenomegaly and thrombocytopenia
       secondary to disseminated Mycobacterium avium complex (MAC). The
       patients were treated for immune thrombocytopenic purpura without
       success. Thrombocytopenia may be a prominent feature of MAC. Our
       experience suggests that disseminated MAC may present with acute
       splenomegaly and thrombocytopenia in these patients and that a high
       index of suspicion for disseminated tuberculosis is indispensable in
       order to avoid delay in diagnosis and treatment in patients presenting
       with rapidly progressive splenomegaly and thrombocytopenia.
 DE    Acute Disease  Adult  AIDS-Related Opportunistic
       Infections/COMPLICATIONS/*DIAGNOSIS/  THERAPY  Case Report  Combined
       Modality Therapy  Emergencies  Female  Human
       Hypersplenism/*DIAGNOSIS/ETIOLOGY/THERAPY  *HIV-1  Male  Mycobacterium
       avium Complex/ISOLATION & PURIF  Mycobacterium avium-intracellulare
       Infection/COMPLICATIONS/  *DIAGNOSIS/THERAPY  Splenectomy
       Splenomegaly/DIAGNOSIS/ETIOLOGY/THERAPY
       Thrombocytopenia/*DIAGNOSIS/ETIOLOGY/THERAPY  Tuberculosis,
       Splenic/DIAGNOSIS/ETIOLOGY/THERAPY  JOURNAL ARTICLE

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