Document 0028
 DOCN  M9460028
 TI    Structured group therapy and fluoxetine to treat depression in
       HIV-positive persons.
 DT    9408
 AU    Targ EF; Karasic DH; Diefenbach PN; Anderson DA; Bystritsky A; Fawzy FI;
       Department of Psychiatry, UCSF School of Medicine.
 SO    Psychosomatics. 1994 Mar-Apr;35(2):132-7. Unique Identifier : AIDSLINE
       MED/94225031
 AB    In 1990, 20 asymptomatic persons diagnosed with the human
       immunodeficiency virus (HIV-positive) and mild-to-moderate depression
       were divided into 2 comparison groups. One group received structured
       group therapy plus fluoxetine, while the other received the same therapy
       plus a placebo. Affective, neurocognitive, and immune variables were
       measured before and after the intervention. In the patients receiving
       group therapy and fluoxetine, its administration did not improve
       treatment outcome compared to the therapy and placebo group. No
       significant differences between the two groups were noted on immune
       variables. However, symptoms of depression decreased in both groups, and
       both groups showed significant incorporation of the skills in active
       behavioral coping taught in therapy.
 DE    beta 2-Microglobulin/ANALYSIS/METABOLISM  Adaptation, Psychological
       Antigens, CD/ANALYSIS/DRUG EFFECTS  Cognition/DRUG EFFECTS  Combined
       Modality Therapy  Comparative Study  Depressive Disorder/*DRUG
       THERAPY/*ETIOLOGY/IMMUNOLOGY
       Fluoxetine/IMMUNOLOGY/PHARMACOLOGY/*THERAPEUTIC USE  Human  HIV
       Seropositivity/IMMUNOLOGY/*PSYCHOLOGY/THERAPY  Placebos  Psychotherapy
       Psychotherapy, Group  Support, Non-U.S. Gov't  Treatment Outcome
       CLINICAL TRIAL  JOURNAL ARTICLE  RANDOMIZED CONTROLLED TRIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).