Document 0044
 DOCN  M9460044
 TI    Pyoderma gangrenosum in infants and children.
 DT    9408
 AU    Graham JA; Hansen KK; Rabinowitz LG; Esterly NB; Department of
       Pediatrics, Medical College of Wisconsin Milwaukee.
 SO    Pediatr Dermatol. 1994 Mar;11(1):10-7. Unique Identifier : AIDSLINE
       MED/94224664
 AB    Pyoderma gangrenosum is an uncommon ulcerative skin disorder that occurs
       in all age groups. Approximately 4% of patients are infants and
       children. There are several notable differences between the childhood
       and adult manifestations of the disease, including the distribution of
       lesions and associated disorders. We reviewed the childhood cases (< or
       = 18 yrs of age) of unequivocal pyoderma gangrenosum in the English
       literature and tabulated the trends in clinical features, associated
       disorders, and therapy. We report our 3-week-old patient, the youngest
       documented case. Of the 46 patients, only 4 were less than 1 year of
       age. A systemic illness was present in 74% of the older children, most
       commonly, ulcerative colitis. Only one infant had an associated problem
       (HIV+) at the time of onset. Infants appear to have an unusual
       distribution of perianal and genital lesions not often described in
       other age groups. Our review suggests that pyoderma gangrenosum in
       children has a similar clinical appearance to that in adults. It is
       associated with some of the same underlying disorders, but with
       different frequencies. The distribution of lesions in children is
       similar, often involving the lower extremities, but pyoderma gangrenosum
       of the head and face appears to be more common in children. Infants may
       have ulcers in genital and perianal areas. The most frequently
       prescribed treatment for children is systemic corticosteroids, which
       generally are very effective.
 DE    Adolescence  Anus Diseases/DRUG THERAPY/PATHOLOGY  Case Report  Child
       Follow-Up Studies  Genital Diseases, Male/DRUG THERAPY/PATHOLOGY  Human
       Infant  Infant, Newborn  Male  Perineum/PATHOLOGY
       Prednisone/THERAPEUTIC USE  Pyoderma Gangrenosum/DRUG THERAPY/*PATHOLOGY
       Scrotum/PATHOLOGY  Triamcinolone/THERAPEUTIC USE  JOURNAL ARTICLE
       REVIEW  REVIEW OF REPORTED CASES

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).