Document 0062
 DOCN  M9460062
 TI    Expression of functional Fas antigen on adult T-cell leukemia.
 DT    9408
 AU    Kotani T; Aratake Y; Kondo S; Tamura K; Ohtaki S; Department of
       Laboratory Medicine, Miyazaki Medical College,; Kiyotake, Japan.
 SO    Leuk Res. 1994 Apr;18(4):305-10. Unique Identifier : AIDSLINE
       MED/94223918
 AB    The expression of Fas antigen was analyzed in the peripheral blood
       mononuclear cells of 12 patients with adult T-cell leukemia (ATL) by
       flow cytometry. The induction of apoptosis in these cells by adding an
       anti-Fas antibody and the expression of activated T-cell surface
       antigens, CD25 and CD26, were also studied. It appears that the cells in
       ATL expressed a significantly larger number of Fas antigens than those
       in normal subjects (p < 0.01) and their fluorescent intensity was also
       shown to be much stronger in ATL (p < 0.01). The large number of ATL
       cells showed apoptosis in a short-term culture in the presence of the
       anti-Fas antibody. There was no difference in the expression of Fas
       antigen among ATL cells with different phenotypes of CD4+/CD8-,
       CD4-/CD8- and CD4+/CD8+ as well as with clinical subtypes of ATL.
       Interestingly, the expression of Fas and CD26 antigens showed a negative
       correlation (p < 0.01, r = 0.78). The strong expression of functional
       Fas antigen in ATL leads to the impression that anti-Fas antibody could
       be one of the treatment modalities for ATL which is known to be a very
       difficult disease to cope with.
 DE    Antigens, Differentiation, T-Lymphocyte/ANALYSIS  Antigens,
       Surface/*IMMUNOLOGY  Apoptosis  CD4-CD8 Ratio  Human  Leukemia,
       T-Cell/*IMMUNOLOGY/PATHOLOGY  Lymphocyte Transformation  Receptors,
       Interleukin-2/ANALYSIS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).