Document 0085
 DOCN  M9460085
 TI    Primary acute simian immunodeficiency virus infection of intestinal
       lymphoid tissue is associated with gastrointestinal dysfunction.
 DT    9408
 AU    Heise C; Miller CJ; Lackner A; Dandekar S; Department of Internal
       Medicine, University of California, Davis; 95616.
 SO    J Infect Dis. 1994 May;169(5):1116-20. Unique Identifier : AIDSLINE
       MED/94223075
 AB    Human immunodeficiency virus (HIV)-associated intestinal abnormalities
       can occur before immunodeficiency or infection with opportunistic
       enteropathogens. Rhesus macaques infected with simian immunodeficiency
       virus (SIV) develop an AIDS-like illness that frequently includes
       enteropathy. The development of enteropathy and its association with SIV
       infection in the intestinal tract was examined. By 1 week after
       infection, SIV-infected macrophages and T lymphocytes were detected in
       gut-associated lymphoid tissue. In contrast to findings in the
       asymptomatic stage, SIV-infected macrophages were numerous in primary
       and terminal stages of infection. An acute enteropathy syndrome was
       observed in the primary acute stage of infection. Functional
       abnormalities of absorptive epithelium, indicated by D-xylose
       malabsorption and decreased sucrase activity, occurred before the onset
       of diarrhea or opportunistic enteric infections. These findings indicate
       that macrophages and T cells in the intestinal tract are early targets
       of SIV infection and may play a critical role in the development of
       SIV-associated intestinal dysfunction.
 DE    Acute Disease  Animal  Female  Gastrointestinal
       System/MICROBIOLOGY/PATHOLOGY/*PHYSIOPATHOLOGY  Intestinal Absorption
       Lymphoid Tissue/*MICROBIOLOGY  Macaca mulatta  Macrophages/MICROBIOLOGY
       Male  Simian Acquired Immunodeficiency Syndrome/PATHOLOGY/
       *PHYSIOPATHOLOGY  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes/MICROBIOLOGY  Xylose/METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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