Document 0114
 DOCN  M9460114
 TI    Mice with an acquired immunodeficiency (MAIDS) develop a persistent
       infection after injection with Listeria monocytogenes.
 DT    9408
 AU    Hugin AW; Cerny A; Morse HC 3rd; Laboratory of Immunopathology, NIAID,
       National Institutes of; Health, Bethesda, Maryland 20892.
 SO    Cell Immunol. 1994 Apr 15;155(1):246-52. Unique Identifier : AIDSLINE
       MED/94221662
 AB    Mice with a retrovirus-induced immunodeficiency were challenged with
       Listeria monocytogenes and resistance to this facultative intracellular
       bacterium was analyzed. Early innate immunity was unaltered or enhanced.
       Although immunodeficient mice had reduced bacterial titers after these
       reached their peak on Day 3, infection with L. monocytogenes generally
       resulted in a low-grade persistent infection and occasionally there was
       a delayed resolution of bacterial infection. Endogenous cytokines are
       important in the containment of bacteria as mice often developed a high
       load of bacteria or succumbed to infection in the absence of cytokine
       action. There was a substantial heterogeneity in disease after bacterial
       challenge which probably reflects the variability found in
       retrovirus-infected mice during the later stages of this
       immunodeficiency syndrome.
 DE    Animal  Chronic Disease  Cytokines/BIOSYNTHESIS  Immunity, Natural
       Listeria Infections/COMPLICATIONS/DRUG THERAPY/*IMMUNOLOGY
       Liver/MICROBIOLOGY  Mice  Mice, Inbred C57BL  Murine Acquired
       Immunodeficiency Syndrome/COMPLICATIONS/  *IMMUNOLOGY  Phagocytosis
       Reticuloendothelial System/*IMMUNOLOGY  Spleen/MICROBIOLOGY  Survival
       Analysis  JOURNAL ARTICLE

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