Document 0139
 DOCN  M9460139
 TI    [Hypercalcemia of T-cell leukemia in adults]
 DT    9408
 AU    Jean-Baptiste G; Arfi S; Plumelle Y; Panelatti G; Mangin JL; Pascaline
       N; Service de Rhumatologie, CHU, Fort-de-France.
 SO    Rev Rhum Ed Fr. 1993 Apr;60(4):292-8. Unique Identifier : AIDSLINE
       MED/94221028
 AB    A retrospective study of 26 adults with acute T-cell leukemia showed
       that 14 patients (54%) had hypercalcemia at some point of the disease.
       Hypercalcemia was found at presentation in nine patients and revealed
       the disease in one. Eight patients had hypercalcemia at the time of
       death. Serum phosphorus and parathyroid hormone levels were normal. All
       patients with hypercalcemia tested positive for the HTLV-1 by Elisa and
       Western blot. Six patients had focalized or diffuse lytic
       roentgenographic bone lesions. Hypercalcemia in acute T-cell leukemia
       may involve production of interleukin-1-alpha and parathyroid
       hormone-related protein by HTLV-1-infected cells.
 DE    Adult  Aged  Aged, 80 and over  English Abstract  Female  Human
       Hypercalcemia/DIAGNOSIS/*ETIOLOGY  HTLV-I
       Infections/BLOOD/*COMPLICATIONS  Leukemia, T-Cell/BLOOD/*COMPLICATIONS
       Male  Middle Age  Parathyroid Hormones/BLOOD  Phosphorus/BLOOD
       Proteins/ANALYSIS  Retrospective Studies  JOURNAL ARTICLE

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