Document 0185
 DOCN  M9460185
 TI    Absence of HTLV-1 related sequences in MS from high prevalence areas in
       western Norway.
 DT    9408
 AU    Myhr KM; Frost P; Gronning M; Midgard R; Kalland KH; Helland DE; Nyland
       HI; Department of Neurology, University of Bergen, Norway.
 SO    Acta Neurol Scand. 1994 Jan;89(1):65-8. Unique Identifier : AIDSLINE
       MED/94233931
 AB    In Western Norway, long-term follow up epidemiological studies have
       revealed significant increases in the incidence and prevalence rates of
       multiple sclerosis (MS) in stable populations, indicating the impact of
       exogenous factors. In this study 183 MS patients and 102 controls from
       high prevalence areas in Western Norway were investigated for human
       T-lymphotropic virus type I (HTLV-1) related sequences by polymerase
       chain reaction. Using primers targeting the gag, pol and env genes in
       the HTLV-1 provirus genome, no amplification products were detected in
       the 183 MS patients or 102 controls. The results strongly suggest that
       neither HTLV-1 nor a closely related retrovirus participate in the
       aetiology of MS.
 DE    Adult  Blotting, Southern  Cross-Sectional Studies  Female  Human
       HTLV-I Infections/*EPIDEMIOLOGY  Incidence  Male  Middle Age  Multiple
       Sclerosis/*EPIDEMIOLOGY  Norway/EPIDEMIOLOGY  Polymerase Chain Reaction
       Risk Factors  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).