Document 0194
 DOCN  M9460194
 TI    Growth failure and AIDS-like cachexia syndrome in HIV-1 transgenic mice.
 DT    9408
 AU    Santoro TJ; Bryant JL; Pellicoro J; Klotman ME; Kopp JB; Bruggeman LA;
       Franks RR; Notkins AL; Klotman PE; Department of Medicine, University of
       Colorado Health Sciences; Center, Denver 80220.
 SO    Virology. 1994 May 15;201(1):147-51. Unique Identifier : AIDSLINE
       MED/94233764
 AB    The mechanisms which predispose to growth failure in infants and
       children infected with immunodeficiency virus type-1 (HIV-1) are not
       fully understood. The contributions of viral replication and CD4+ T cell
       depletion to growth failure in an HIV-1 transgenic mouse model were
       investigated. Mice homozygous for the transgene, a gag-pol deletion
       mutant of the HIV-1 provirus pNL4-3, exhibited marked cachexia, growth
       retardation, lymphoproliferation with a reduction in the percentage of
       CD4+ T cells but an increase in the absolute number of splenic CD4+ and
       CD8+ T cells, thymic hypoplasia, and early death. Despite the absence of
       T cells, athymic nude mice, homozygous for the HIV transgene, displayed
       comparable growth failure. The results indicate that AIDS-like cachexia
       may be produced by expression of viral envelope or accessory genes, need
       not be accompanied by absolute depletion of CD4+ T cells, and may occur
       independent of T cell function.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*MICROBIOLOGY/
       PHYSIOPATHOLOGY  Animal  Animals, Newborn  Body Weight
       Cachexia/IMMUNOLOGY/*MICROBIOLOGY/PHYSIOPATHOLOGY  Female  Fusion
       Proteins, gag-pol/GENETICS  Gene Expression  Gene Products, nef/ANALYSIS
       *Genes, Viral  Homozygote  HIV-1/*GENETICS  Immunophenotyping  Male
       Mice  Mice, Transgenic  RNA, Viral/ANALYSIS  T4 Lymphocytes/*IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).