Document 0197
 DOCN  M9460197
 TI    Restricted herpes simplex virus type 1 gene expression within sensory
       neurons in the absence of functional B and T lymphocytes.
 DT    9408
 AU    Gesser RM; Valyi-Nagy T; Fraser NW; Wistar Institute, Philadelphia,
       Pennsylvania 19104.
 SO    Virology. 1994 May 1;200(2):791-5. Unique Identifier : AIDSLINE
       MED/94233743
 AB    Herpes simplex virus type I (HSV-1) establishes a latent infection in
       sensory ganglion neurons. During latency no viral-specific proteins are
       detected and virus gene expression is restricted to the
       latency-associated transcripts. We report here that trigeminal ganglia
       of mice with severe combined immunodeficiency contain individual sensory
       neurons exhibiting restricted viral gene expression characteristic of
       latency; this occurred during acute (4-6 days) infection with the
       wild-type HSV-1 strain 17+ and after prolonged (4 weeks) infection with
       the replication impaired HSV-1 mutant in 1814. These results indicate
       that T and B lymphocytes, while important for the recovery from viral
       infections, are not required for the establishment or maintenance of
       latency in neurons.
 DE    Animal  Comparative Study  Female  Gene Expression  Herpes
       Simplex/*IMMUNOLOGY/METABOLISM  Herpesvirus 1, Human/*GROWTH &
       DEVELOPMENT/GENETICS  Immunohistochemistry  In Situ Hybridization
       Lymphocytes/IMMUNOLOGY  Male  Mice  Mice, Inbred BALB C  Mice, SCID
       Neurons, Afferent/*MICROBIOLOGY  RNA, Messenger/ANALYSIS  Severe
       Combined Immunodeficiency/COMPLICATIONS/VETERINARY  Support, U.S. Gov't,
       P.H.S.  Time Factors  Trigeminal Ganglion/*MICROBIOLOGY  Virus
       Latency/GENETICS  Virus Replication/GENETICS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).