Document 0284
 DOCN  M9460284
 TI    Differences in IL-2 receptor levels between mycosis fungoides and
       cutaneous type adult T-cell leukemia/lymphoma in the early stages of the
       disease.
 DT    9408
 AU    Oishi M; Johno M; Ono T; Honda M; Laboratory of Immunology, National
       Institute of Health, Tokyo,; Japan.
 SO    J Invest Dermatol. 1994 May;102(5):710-5. Unique Identifier : AIDSLINE
       MED/94231025
 AB    Skin lesions in mycosis fungoides (MF) and cutaneous-type adult T-cell
       leukemia/lymphoma (c-ATL) are sometimes difficult to differentiate. Our
       previous investigations showed that the alpha-chain of interleukin-2
       receptor (IL-2R alpha) secretion is enhanced in both acute and chronic
       type ATL. This finding suggested increased levels of IL-2R alpha in
       c-ATL that might differentiate it from MF. In this study, we report
       several observations on IL-2R alpha levels in MF and c-ATL. 1) Plasma
       levels of IL-2R alpha determined by enzyme-linked immunosorbent assay
       were higher in patients with c-ATL (tumor group, 17,571 +/- 5,919 U/ml;
       non-tumor group, 4,546 +/- 1,788 U/ml) than those of patients with MF
       (tumor group, 2,352 +/- 861 U/ml; plaque group, 530 +/- 174 U/ml). 2)
       The percentages of IL-2R alpha-positive cells in skin lesions of c-ATL
       were 30.5 +/- 13.4% in the non-tumor group and 62.7 +/- 12.0% in the
       tumor group, which were significantly higher than those of MF, plaque
       group (12.7 +/- 5.9%), and tumor group (3.4 +/- 2.3%). 3) Further, there
       was a significant correlation between plasma IL-2R alpha levels and the
       number of IL-2R alpha-positive cells in skin lesions in patients with
       c-ATL (r = 0.654, p < 0.0001) and MF (r = 0.537, p < 0.01) on an
       individual basis; whereas no increased IL-2R alpha levels in peripheral
       blood mononuclear cells were observed in patients with either MF or
       c-ATL. 4) Skin lesions of c-ATL had much higher levels of IL-2R alpha
       genomic RNA than those of MF in their initial stages when measured by
       DNase/reverse transcription/polymerase chain reaction and liquid
       hybridization analysis. These findings suggest that increased plasma
       IL-2R alpha levels in patients with either MF or c-ATL may be linked to
       cellular IL-2R alpha levels in the skin lesions, and thus reflect the
       difference between MF and c-ATL.
 DE    Adult  Aged  Female  Human  Leukemia-Lymphoma, T-Cell, Acute,
       HTLV-I-Associated/BLOOD/  *METABOLISM  Leukocytes, Mononuclear/CHEMISTRY
       Male  Middle Age  Mycosis Fungoides/BLOOD/*METABOLISM  Polymerase Chain
       Reaction/METHODS  Receptors, Interleukin-2/*ANALYSIS/GENETICS  RNA,
       Messenger/ANALYSIS  Skin Neoplasms/*CHEMISTRY  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

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