Document 0339
 DOCN  M9460339
 TI    Interaction of human plasma fibronectin with viral proteins of human
       immunodeficiency virus.
 DT    9408
 AU    Torre D; Pugliese A; Ferrario G; Marietti G; Forno B; Zeroli C; Division
       of Infectious Diseases, Regional Hospital, Varese,; Italy.
 SO    FEMS Immunol Med Microbiol. 1994 Feb;8(2):127-31. Unique Identifier :
       AIDSLINE MED/94227795
 AB    Fibronectin (FN) is present in soluble and matrix forms in various body
       fluids and tissues, and has been shown to bind to several pathogens,
       including viruses. The interaction of FN with viral proteins of human
       immunodeficiency virus (HIV-1) was investigated by immunofluorescence
       technique using a cell line chronically infected with HIV-1 (H9-V). The
       results of this study showed that FN binds to HIV-1 infected cells,
       especially at FN concentration of 5 micrograms/ml. In addition,
       FN-pentapeptide has shown the ability to bind to HIV-1 infected cells.
       On the other hand, preincubation with antibodies against FN abolished
       the binding of FN to HIV-1 infected cells. Finally, FN has shown to bind
       to HIV-1 glycoproteins, including gp41 and gp120. In contrast, no
       binding to HIV-1 core proteins, including p15 and p24, was noted. We
       suggest that FN, in binding HIV-1 particles, may reduce viremia and thus
       may be involved in the clearance of viral proteins from the cells.
 DE    Comparative Study  Dose-Response Relationship, Drug  Enzyme-Linked
       Immunosorbent Assay  Fibronectins/BLOOD/IMMUNOLOGY/*METABOLISM  Human
       HIV Envelope Protein gp120/*METABOLISM  HIV Envelope Protein
       gp41/*METABOLISM  HIV-1/*METABOLISM  Oligopeptides/METABOLISM  Peptide
       Fragments/METABOLISM  JOURNAL ARTICLE

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