Document 0749
 DOCN  M9470749
 TI    Demyelination and ethnicity: experience at the University of British
       Columbia Multiple Sclerosis Clinic with special reference to
       HTLV-I-associated myelopathy in British Columbian natives.
 DT    9409
 AU    Oger J; Lai H; Multiple Sclerosis Clinic, University Hospital,
       University of; British Columbia, Vancouver, Canada.
 SO    Ann Neurol. 1994;36 Suppl:S22-4. Unique Identifier : AIDSLINE
       MED/94288567
 AB    Since its creation in 1980, the Multiple Sclerosis Clinic at the
       University of British Columbia has actively followed over 2,500 patients
       from the Canadian province of British Columbia (BC) who have clinically
       definite multiple sclerosis (MS). These patients include 2,496 European
       Caucasians from a BC population of 3,858,505 (prevalence 64.7/100,000)
       in contrast with 92 patients of other ethnic origin (prevalence
       14.6/100,000). Prevalence was higher in South Asians (15.7 from a
       population of 114,355) than in East Asians (6.25 from 287,845). Among
       individuals with native ancestry, MS was not rare when there was also
       European ancestry (46 cases from a population of 94,615), but MS was not
       encountered in pure-blooded natives (0 cases from 74,420 individuals).
       In contrast, among 5 patients with HTLV-I-associated myelopathy (HAM), 4
       (from a population of 74,420) were of single native ancestry and only 1
       (from a population of 94,615) was of multiple ancestry, including native
       ancestry. HAM was not found among Caucasians. This preliminary account
       clearly establishes that HAM is linked to native ancestry and that MS is
       linked to Caucasian ancestry.
 DE    British Columbia/EPIDEMIOLOGY  Canada/EPIDEMIOLOGY  Caucasoid
       Race/GENETICS  Europe/ETHNOLOGY  Far East/ETHNOLOGY  Human  Indians,
       North American/STATISTICS & NUMER DATA  Linkage (Genetics)  Multiple
       Sclerosis/EPIDEMIOLOGY/*GENETICS  Paraparesis, Tropical
       Spastic/EPIDEMIOLOGY/*GENETICS  Prevalence  Racial Stocks/*GENETICS
       JOURNAL ARTICLE

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