Document 0763
 DOCN  M9470763
 TI    Maternal-infant HIV transmission and circumstances of delivery [see
       comments]
 DT    9409
 AU    Kuhn L; Stein ZA; Thomas PA; Singh T; Tsai WY; Division of Epidemiology,
       Columbia University, New York, NY; 10032.
 SO    Am J Public Health. 1994 Jul;84(7):1110-5. Unique Identifier : AIDSLINE
       MED/94288167
 CM    Comment in: Am J Public Health 1994 Jul;84(7):1065-6
 AB    OBJECTIVES. Circumstances of delivery among children with acquired
       immunodeficiency syndrome (AIDS) were investigated to assess whether
       they were consistent with predictions that intrapartum factors affect
       the risk of maternal-infant human immunodeficiency virus (HIV)
       transmission. METHODS. Pediatric AIDS patients (maternal-infant
       transmission; n = 632) reported to the New York City Health Department
       through 1991 were compared with a series of infants born to
       predominantly uninfected women. For each case patient, five control
       subjects were selected and matched from birth certificate files.
       Hypothesized case-control comparisons for mode of delivery and
       preselected complications were tested. RESULTS. Compared with control
       subjects, case patients were less likely to have been delivered by
       cesarean section without complications (odds ratio [OR] = 0.77; 95%
       confidence interval [CI] = 0.59, 1.01) and more likely to have been
       delivered with complications, whether delivery was by cesarean section
       (OR = 1.54; 95% CI = 0.98, 2.43) or vaginal (OR = 1.66; 95% CI = 1.15,
       2.39). CONCLUSIONS. Assuming that HIV-infected and uninfected women have
       comparable circumstances of delivery, conditional on sociomedical
       characteristics, these results suggest that intrapartum events may be
       associated with maternal-infant HIV transmission.
 DE    Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY  Case-Control Studies
       Child  Child, Preschool  *Delivery  Female  Human  HIV
       Infections/*TRANSMISSION  Infant  Infant, Newborn  *Labor Complications
       Logistic Models  Male  Pregnancy  Risk Factors  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).