Document 0769
 DOCN  M9470769
 TI    AIDS-associated cryptosporidiosis with gastric stricture and a
       therapeutic response to paromomycin.
 DT    9409
 AU    Forester G; Sidhom O; Nahass R; Andavolu R; Department of Medicine,
       Robert Wood Johnson Medical School and; Medical Center at Princeton, New
       Jersey.
 SO    Am J Gastroenterol. 1994 Jul;89(7):1096-8. Unique Identifier : AIDSLINE
       MED/94287995
 AB    AIDS-associated cryptosporidiosis has been associated with severe,
       watery diarrhea and with multifocal biliary stricture. Gastric
       involvement has not been reported prominently. We report here the case
       of a 28-yr-old AIDS patient who developed typical watery diarrhea,
       followed by subtotal gastric obstruction secondary to antral
       stricturing. Biopsy of the stricture revealed severe inflammation and
       marked cryptosporidial infestation. Extensive workup excluded causes of
       stricture. He was empirically treated with paromomycin, with a
       surprisingly positive therapeutic response and clinical resolution of
       obstruction. Antral stricture may be another manifestation of
       cryptosporidial infection in AIDS. Paromomycin deserves further
       evaluation as an agent for treatment of this infection.
 DE    Adult  AIDS-Related Opportunistic Infections/*COMPLICATIONS/DRUG THERAPY
       Case Report  Cryptosporidiosis/*COMPLICATIONS/DRUG THERAPY  Gastric
       Outlet Obstruction/*ETIOLOGY  Gastritis/COMPLICATIONS/DRUG
       THERAPY/*PARASITOLOGY  Human  Male  Paromomycin/*THERAPEUTIC USE
       JOURNAL ARTICLE

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