Document 0774
 DOCN  M9470774
 TI    [Immunocytophotometric and cytogenetic analyses of T-lymphoblastoid cell
       lines in experimental HIV Infection]
 DT    9409
 AU    Kushch AA; Shumai EP; Glukhova LA; Magakin IuA; Avetisian AS; Kapantsian
       AM; Karalova EM; Grabovskaia IL
 SO    Vopr Virusol. 1994 Mar-Apr;39(2):77-80. Unique Identifier : AIDSLINE
       MED/94287661
 AB    The accumulation of viral proteins p24 and gp41 in MT-4 cells was shown
       to occur asynchronously. No increase in the number of polydiploid cells,
       no polyploid mitoses or chromosome defects were found indicating the
       antiproliferative effect of HIV on MT-4 cells. A cyclic pattern of the
       infection course was observed in infected Jurkat-tat cells. The
       accumulation of viral proteins was concerted, their maximum amounts
       preceding the cell death. HIV-1 did not inhibit cell division and caused
       strong disorders in the chromosome structure.
 DE    Acute Disease  Cell Line  Cells, Cultured/METABOLISM/MICROBIOLOGY
       *Chromosome Aberrations  Comparative Study  Cytopathogenic Effect, Viral
       Cytophotometry  English Abstract  Human  HIV Core Protein p24/METABOLISM
       HIV Envelope Protein gp41/METABOLISM  HIV
       Infections/GENETICS/METABOLISM/*MICROBIOLOGY  HIV-1/*PATHOGENICITY
       Immunohistochemistry  Polyploidy  T-Lymphocytes/METABOLISM/*MICROBIOLOGY
       Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).