Document 0783
 DOCN  M9470783
 TI    Epidemiology and etiopathology of human T-lymphotropic viruses:
       diagnostic and clinical implications for non-endemic areas.
 DT    9409
 AU    Del Mistro A; Calabro ML; Favero A; Chieco-Bianchi L; Istituto di
       Oncologia, Universita di Padova, Italy.
 SO    Tumori. 1994 Apr 30;80(2):88-100. Unique Identifier : AIDSLINE
       MED/94287504
 AB    Human T-lymphotropic viruses (HTLV) type I and II were first described
       more than a decade ago. HTLV-I epidemiology and etiopathology are more
       defined than those of HTLV-II, but conflicting results have been
       obtained in seroepidemiologic surveys, mainly for difficulties in the
       discrimination between the two infections. The introduction of advanced
       serologic and molecular assays has recently provided sensitive and
       specific tools for diagnosis, and the epidemiologic and etiopathologic
       patterns linked to these retroviruses are being more precisely defined.
       Moreover, extensive nucleotide sequence analyses performed so far have
       mainly focused on HTLV-I isolates. The recent discovery of new HTLV-II
       endemic areas and the isolation of HTLV-II strains from intravenous drug
       users have finally provided the material for the molecular
       characterization of HTLV-II isolates, which is now a rapidly envolving
       field. We review the diagnostic strategies available and the etiologic
       associations reported so far for both viruses and also discuss the
       occurrence and significance of indeterminate serologic reactivities
       observed in both endemic and non-endemic areas.
 DE    Human  *HTLV Infections/DIAGNOSIS/EPIDEMIOLOGY/MICROBIOLOGY  Risk
       Factors  Serodiagnosis  Support, Non-U.S. Gov't  JOURNAL ARTICLE  REVIEW
       REVIEW, MULTICASE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).