Document 0812
 DOCN  M9470812
 TI    Oral manifestations associated with HIV-related disease as markers for
       immune suppression and AIDS.
 DT    9409
 AU    Glick M; Muzyka BC; Lurie D; Salkin LM; Temple University School of
       Dentistry, Philadelphia, Pa.
 SO    Oral Surg Oral Med Oral Pathol. 1994 Apr;77(4):344-9. Unique Identifier
       : AIDSLINE MED/94286224
 AB    BACKGROUND. Oral lesions are common findings in HIV-related disease, but
       little is known about their significance in predicting immune
       suppression among a representative group of HIV-infected persons.
       METHODS. Oral examinations were performed on 454 patients who came to an
       outpatient dental clinic for dental care. CD4+ cell counts were obtained
       within 2 months of the examination. RESULTS. In persons with a specific
       lesion and a CD4+ cell count below 200 cells/mm3 the corresponding mean
       CD4+ cell counts and predictive values were 149.5 cells/mm3 and 69.9%
       for candidiasis, 143.3 cells/mm3 and 70.1% for oral hairy leukoplakia,
       126.0 cells/mm3 and 69.4% for xerostomia, 51.8 cells/mm3 and 95.1% for
       necrotizing ulcerative periodontitis, 98.7 cells/mm3 and 87.0% for
       long-standing herpes simplex virus infections, 66.6 cells/mm3 and 93.6%
       for Kaposi's sarcoma, and 33.7 cells/mm3 and 100% for major aphthous
       ulcers. The mean CD4+ cell count declined with increased numbers of
       different concurrent lesions. CONCLUSION. The presence of specific oral
       manifestations and the number of different concurrent intraoral lesions
       among HIV-infected persons are associated with severe immune suppression
       and AIDS. Oral examinations are an essential component for early
       recognition of disease progression and comprehensive evaluation of
       HIV-infected patients.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/IMMUNOLOGY  Adult
       Biological Markers  Candidiasis, Oral/ETIOLOGY/IMMUNOLOGY  *CD4-CD8
       Ratio  Female  Gingivitis, Necrotizing Ulcerative/ETIOLOGY/IMMUNOLOGY
       Human  HIV Infections/BLOOD/COMPLICATIONS/*IMMUNOLOGY  Immunocompromised
       Host/*IMMUNOLOGY  Leukoplakia, Hairy/ETIOLOGY/IMMUNOLOGY  Male  Mouth
       Diseases/BLOOD/ETIOLOGY/*IMMUNOLOGY  Odds Ratio  Predictive Value of
       Tests  Prevalence  Sarcoma, Kaposi's/ETIOLOGY/IMMUNOLOGY  Sensitivity
       and Specificity  Severity of Illness Index  Stomatitis,
       Aphthous/ETIOLOGY/IMMUNOLOGY  Stomatitis, Herpetic/ETIOLOGY/IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).