Document 0813
 DOCN  M9470813
 TI    Prophylactic application of an intra-alveolar socket medicament to
       reduce postextraction complications in HIV-seropositive patients.
 DT    9409
 AU    Pankhurst CL; Lewis DA; Clark DT; Kings College School of Medicine and
       Dentistry, London, England.
 SO    Oral Surg Oral Med Oral Pathol. 1994 Apr;77(4):331-4. Unique Identifier
       : AIDSLINE MED/94286221
 AB    A prospective, controlled trial was performed to investigate the effect
       of a prophylactic socket medicament containing chlortetracycline,
       aspirin, and local anesthetics, in reducing the incidence of
       postextraction pain and infection in patients who are HIV-seropositive.
       Fifty patients were in the study; 25 received the experimental dressing
       and 25 had no dressing. Patients were asked to complete a questionnaire
       rating the pain at 24 hours and 48 hours after surgery. Seven days after
       extraction, socket healing was scored, and sockets with delayed healing
       sampled for culture. Four of 25 (16%) patients who received the
       experimental dressing and 8 of 25 (32%) controls experienced pain during
       the 48 hours after extraction (p = not significant). None of the group
       who received the experimental dressing and 7 of 25 (28%) in the control
       group had delayed healing, of these 4 had alveolar osteitis and three
       had infected sockets (p = 0.0096). We conclude that the experimental
       agent is useful as a prophylactic agent to reduce delayed healing in
       HIV-positive patients who undergo exodontia.
 DE    Acquired Immunodeficiency Syndrome  Adult  Anesthetics,
       Local/*THERAPEUTIC USE  Aspirin/THERAPEUTIC USE
       Chlortetracycline/THERAPEUTIC USE  Dental Care for Chronically
       Ill/*METHODS  Dibucaine  Dry Socket/ETIOLOGY/*PREVENTION & CONTROL
       Female  Human  *HIV Infections  HIV Seropositivity  Male  Middle Age
       *Occlusive Dressings  Support, Non-U.S. Gov't  Surgical Wound
       Infection/MICROBIOLOGY/PREVENTION & CONTROL  *Tooth Extraction/ADVERSE
       EFFECTS  Wound Healing  CLINICAL TRIAL  JOURNAL ARTICLE  RANDOMIZED
       CONTROLLED TRIAL

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