Document 0839
 DOCN  M9470839
 TI    Prolonged clinical latency and survival of macaques given a whole
       inactivated simian immunodeficiency virus vaccine.
 DT    9409
 AU    Hirsch VM; Goldstein S; Hynes NA; Elkins WR; London WT; Zack PM;
       Montefiori D; Johnson PR; Immunodeficiency Viruses Section, National
       Institute of Allergy; and Infectious Diseases, National Institutes of
       Health, Bethesda,; Maryland.
 SO    J Infect Dis. 1994 Jul;170(1):51-9. Unique Identifier : AIDSLINE
       MED/94284661
 AB    Simian immunodeficiency virus (SIV) infection of macaques is a useful
       and relevant model for evaluating candidate human immunodeficiency virus
       (HIV) vaccines. One important feature of this model is that SIV vaccines
       can be evaluated for their ability to prevent infection as well as to
       prevent or delay the onset of AIDS. In the present study, a group of
       macaques was vaccinated with whole inactivated SIV and challenged with
       peripheral blood mononuclear cells from an SIV-infected macaque. This
       challenge represented a rigorous and realistic test of the immunization
       protocol. All macaques became infected after challenge; however,
       immunized animals survived significantly longer (P < .03) than naive
       controls. These data suggest that similar vaccines administered to
       humans at risk for HIV-1 infection might delay or prevent AIDS even if
       the vaccine failed to prevent infection.
 DE    Amino Acid Sequence  Animal  Antibodies, Viral/BLOOD  Antigens,
       Viral/BLOOD  AIDS Vaccines  Base Sequence  Cells, Cultured  DNA, Viral
       Human  Macaca nemestrina  Molecular Sequence Data
       Monocytes/MICROBIOLOGY  Sequence Homology, Amino Acid  Simian Acquired
       Immunodeficiency Syndrome/IMMUNOLOGY/MORTALITY/  *PREVENTION &
       CONTROL/PHYSIOPATHOLOGY  SIV/IMMUNOLOGY/PHYSIOLOGY  T-Lymphocyte
       Subsets/IMMUNOLOGY  Vaccines, Inactivated/IMMUNOLOGY  Viral
       Vaccines/*IMMUNOLOGY  Virus Latency  JOURNAL ARTICLE

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