Document 0840
 DOCN  M9470840
 TI    Clustering of human T lymphotropic virus type I seropositive in
       Montserrat, West Indies: evidence for an environmental factor in
       transmission of the virus.
 DT    9409
 AU    Miller GJ; Lewis LL; Colman SM; Cooper JA; Lloyd G; Scollen N; Jones N;
       Tedder RS; Greaves MF; Medical Research Council Epidemiology and Medical
       Care Unit,; Medical College of St. Bartholomew's Hospital, London.
 SO    J Infect Dis. 1994 Jul;170(1):44-50. Unique Identifier : AIDSLINE
       MED/94284660
 AB    A community survey of human T cell lymphotropic virus type I (HTLV-I) in
       Montserrat, West Indies, identified 22 instances in which 2
       HTLV-I-seropositive adults lived within 60 m of each other (close
       pairs), compared with 7.8 expected (P < .001). Five of these close pairs
       were mother-offspring or husband-wife. The remaining 17 pairs were of
       unrelated members in separate households. The percentages of male-female
       (41%), female-female (41%), and male-male (18%) types in these 17 pairs
       were very similar to those among the 1377 similarly defined pairs in
       which neither or only 1 member was seropositive, affording no support
       for extramarital heterosexual activity as an explanation for the
       clustering observed. Thus, the demography of HTLV-I was not accounted
       for completely by sexual and mother-to-offspring transmission. The
       predominance of clustering of unrelated HTLV-I-seropositive individuals
       in locations with high mosquito infestation raised the possibility of
       sporadic transmission of HTLV-I by hematophagous insects.
 DE    Adolescence  Adult  Aedes  Aged  Aged, 80 and over  Animal  Antibodies,
       Viral/ANALYSIS  Demography  Dengue/EPIDEMIOLOGY  Environmental Exposure
       Female  Human  HTLV-I Infections/*EPIDEMIOLOGY/TRANSMISSION  Insect
       Vectors  Male  Middle Age  Support, Non-U.S. Gov't  West
       Indies/EPIDEMIOLOGY  JOURNAL ARTICLE

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