Document 0843
 DOCN  M9470843
 TI    Human herpesvirus 6: a survey of presence and variant distribution in
       normal peripheral lymphocytes and lymphoproliferative disorders.
 DT    9409
 AU    Di Luca D; Dolcetti R; Mirandola P; De Re V; Secchiero P; Carbone A;
       Boiocchi M; Cassai E; Institute of Microbiology, University of Ferrara,
       Italy.
 SO    J Infect Dis. 1994 Jul;170(1):211-5. Unique Identifier : AIDSLINE
       MED/94284641
 AB    The presence and distribution of human herpesvirus 6 (HHV-6) variants
       was investigated by polymerase chain reaction in samples from healthy
       donors and biopsies from non-Hodgkin's lymphomas and Hodgkin's disease.
       HHV-6 DNA was present in peripheral blood lymphocytes of 17% of healthy
       donors, variant B three times more frequently than A. HHV-6 was not
       present in 35 non-Hodgkin's lymphomas of B cell origin and was in only 1
       of 10 non-Hodgkin's lymphomas in AIDS patients. HHV-6 DNA was present in
       29% of Hodgkin's disease samples; variant B was more frequent than A.
       Epstein-Barr virus DNA was detected in 38% of Hodgkin's disease biopsies
       and did not correlate with HHV-6. Thus, the two HHV-6 variants are
       differently distributed in the healthy population, and the virus
       probably has no direct role in the development of B cell non-Hodgkin's
       lymphoma. The detection of HHV-6 DNA in about one-third of Hodgkin's
       disease biopsies suggests that HHV-6 might be associated with a subset
       of this disorder.
 DE    DNA, Viral/GENETICS/ISOLATION & PURIF  Herpesvirus 6,
       Human/GENETICS/*ISOLATION & PURIF  Hodgkin's Disease/*MICROBIOLOGY
       Human  Lymphocytes/*MICROBIOLOGY  Lymphoma, Non-Hodgkin's/*MICROBIOLOGY
       Polymerase Chain Reaction  Sensitivity and Specificity  Support,
       Non-U.S. Gov't  Variation (Genetics)  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).