Document 0844
 DOCN  M9470844
 TI    Transmission of human T cell lymphotropic virus (HTLV) type II by
       transfusion of HTLV-I-screened blood products.
 DT    9409
 AU    Rios M; Khabbaz RF; Kaplan JE; Hall WW; Kessler D; Bianco C; New York
       Blood Center, NY 10021.
 SO    J Infect Dis. 1994 Jul;170(1):206-10. Unique Identifier : AIDSLINE
       MED/94284640
 AB    Blood donors have been screened for antibodies to human T cell
       lymphotropic virus (HTLV) type I since December 1988. Screening for
       HTLV-II has been simultaneously done because of cross-reactivity between
       antibodies to the two viruses. Currently, < 1 in 10,000 US blood donors
       is positive for HTLV-I or -II. Lookback studies led to the
       identification of 6 HTLV-II-infected patients. Three received
       transfusions before introduction of HTLV-I screening tests, while the
       other 3 received blood components that tested negative for HTLV-I. The
       HTLV-II subtypes of each of 4 donor/recipient pairs, as determined by
       DNA amplification using polymerase chain reaction, were identical,
       supporting the view that transfusions were the source of infection. In
       conclusion, currently licensed blood donor screening tests for HTLV-I
       lack sensitivity for HTLV-II, and transfusion of blood from
       HTLV-II-infected donors that test negative on HTLV-I screening tests may
       result in infection.
 DE    Adult  Aged  Blood/MICROBIOLOGY  Blood Donors  Blood
       Transfusion/*ADVERSE EFFECTS  Enzyme-Linked Immunosorbent Assay  Female
       Human  HTLV-I/*ISOLATION & PURIF  HTLV-II/*ISOLATION & PURIF  HTLV-II
       Infections/*TRANSMISSION  Infant  Infant, Newborn  Middle Age
       Sensitivity and Specificity  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).