Document 0846
 DOCN  M9470846
 TI    Temporal trends of opportunistic infections and malignancies in
       homosexual men with AIDS.
 DT    9409
 AU    Katz MH; Hessol NA; Buchbinder SP; Hirozawa A; O'Malley P; Holmberg SD;
       Department of Public Health, San Francisco, California; 94102-6033.
 SO    J Infect Dis. 1994 Jul;170(1):198-202. Unique Identifier : AIDSLINE
       MED/94284637
 AB    Temporal changes in the lifetime occurrence of opportunistic infections
       and malignancies among 1115 homosexual men diagnosed with AIDS were
       examined. Information from the AIDS surveillance registry, hospital
       pathology and microbiology logs, patient chart reviews, cancer
       registries, and death certificates was used to calculate the frequency
       of specific opportunistic infections and malignancies as lifetime
       (initial or subsequent) diagnoses. The most common lifetime diagnoses
       were Pneumocystis carinii pneumonia (PCP; 66.5%), Kaposi's sarcoma (KS;
       50.7%), disseminated Mycobacterium avium complex (DMAC) infection
       (29.6%), and cytomegalovirus (CMV) infection (19.6%). From 1981 to 1990,
       there was a significant decrease in the rate of KS (P = .003) and a
       significant increase in the rate of DMAC infection (P = .03). PCP
       decreased during 1985-1990 (P = .009), while CMV infection increased
       from 1987 through 1990 (P = .03). Thus, KS and PCP have declined over
       time, while DMAC and CMV are causing substantial and increasing
       morbidity among AIDS patients.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/EPIDEMIOLOGY  Adult
       AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY  Cohort Studies
       Homosexuality  Human  Male  Neoplasms/*COMPLICATIONS/EPIDEMIOLOGY  San
       Francisco/EPIDEMIOLOGY  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).