Document 0859
 DOCN  M9470859
 TI    Adjuvant effect of liposomes and adamantylamide dipeptide on
       antigenicity of entrapped synthetic peptide derived from HIV-1
       transmembrane region glycoprotein gp41.
 DT    9409
 AU    Turanek J; Toman M; Novak J; Krchnak V; Horavova P; Veterinary Research
       Institute, Brno, Czech Republic.
 SO    Immunol Lett. 1994 Feb;39(2):157-61. Unique Identifier : AIDSLINE
       MED/94283963
 AB    The synthetic peptide antigen (Ag) (the primary structure
       Tyr-Leu-Lys-Asp-Gln-Gln-Leu-Leu-Gly-Ile-Trp-Gly-Cys-Ser-Gly-Lys-L-
       eu-Ile- Cys-Thr derived from the envelope glycoprotein gp41 of the human
       immunodeficiency virus type 1 (HIV-1) and exerting specificity with all
       HIV-1-positive sera available in the Czech Republic (and also in a panel
       of 10,000 sera from WHO)) was conjugated with bovine serum albumin (BSA)
       and encapsulated into liposomes. Adjuvant activities of liposomes with
       various lipid compositions were compared with Freund's complete adjuvant
       (FCA) and with aluminium hydroxide (AL). The immune response to BSA-Ag
       liposomes with coentrapped adamantylamide dipeptide (AdDP) was
       comparable with that of FCA in terms of longevity and levels of specific
       antibodies in mouse sera.
 DE    *Adjuvants, Immunologic  Amantadine/*ANALOGS & DERIVATIVES/IMMUNOLOGY
       Amino Acid Sequence  Animal  Comparative Study  Dipeptides/*IMMUNOLOGY
       Female  Human  HIV Antibodies/IMMUNOLOGY  HIV Antigens/*IMMUNOLOGY  HIV
       Envelope Protein gp41/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY
       Liposomes/*IMMUNOLOGY  Mice  Mice, Inbred BALB C  Molecular Sequence
       Data  Peptides/CHEMICAL SYNTHESIS/*IMMUNOLOGY  Serum Albumin, Bovine
       Vaccines, Synthetic/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).