Document 0871
 DOCN  M9470871
 TI    Corneal endothelial changes in cytomegalovirus retinitis.
 DT    9409
 AU    Mitchell SM; Barton K; Lightman S; Department of Clinical Science,
       Moorfields Eye Hospital, London,; UK.
 SO    Eye. 1994;8 ( Pt 1):41-3. Unique Identifier : AIDSLINE MED/94283687
 AB    Reticular deposits on the corneal endothelium together with fundus
       changes typical of cytomegalovirus (CMV) retinitis have been noted in
       patients with acquired immune deficiency syndrome (AIDS). The aim of
       this study was to characterise this finding using specular microscopy
       and to assess the potential of this clinical sign as a screening tool
       which could be performed rapidly at the slit lamp without the need for
       dilatation of the pupil. Sixty male homosexual patients with a diagnosis
       of AIDS as defined by the Center for Disease Control (Atlanta, 1987)
       were examined at their first visit to the ophthalmic clinic. The cornea
       was examined at the slit lamp prior to fundal examination and the
       presence or absence of the characteristic endothelial changes noted. CMV
       retinitis was diagnosed on the basis of the fundal appearance together
       with confirmation of the diagnosis by analysis of a vitreous sample. As
       a diagnostic sign of CMV retinitis the endothelial changes had a
       positive predictive value of 94.7% and a negative predictive value of
       75.6%. Although the presence of the endothelial changes always indicates
       the presence of CMV retinitis it is not a sign which is found in a high
       enough proportion of patients to allow its reliable use as a screening
       tool.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/PATHOLOGY
       Cytomegalovirus Retinitis/COMPLICATIONS/DIAGNOSIS/*PATHOLOGY
       Endothelium, Corneal/*PATHOLOGY  Human  Male  Predictive Value of Tests
       Sensitivity and Specificity  Support, Non-U.S. Gov't  JOURNAL ARTICLE

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