Document 0884 DOCN M9470884 TI The molecular biology of HIV. Insights into pathogenesis and targets for therapy. DT 9409 AU Zeichner SL; Pediatric Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland. SO Clin Perinatol. 1994 Mar;21(1):39-73. Unique Identifier : AIDSLINE MED/94283009 AB In the past 10 years, a large number of investigators have produced an enormous amount of information concerning the molecular biology of HIV. These studies at the most basic biological level have provided essential insights into the pathogenesis of the disease. They have supplied the information necessary for the creation of the antiviral therapies now available and have indicated the direction for the development of new therapies now in clinical trials and under investigation. Although the relatively ineffective therapies currently available serve as a constant source of disappointment for those practitioners who care for HIV-infected patients, there is some comfort to be gained from the rapid pace of investigation into the basic biology of the virus and the certainty that any more effective therapy must build upon the basic biological knowledge already obtained. A detailed study of some of the unique features observed during pediatric and perinatal HIV infection, particularly the relatively shortened time from infection to symptoms and the relative importance of CNS disease, may suggest new therapeutic approaches that will benefit both adult and pediatric patients. Finally, a comprehensive knowledge of HIV biology is an essential requirement for therapeutic maneuvers designed to interrupt the transmission of HIV from mother to child. DE *DNA, Viral Female Gene Expression Regulation, Viral *Gene Products, env/ANTAGONISTS & INHIB/CHEMISTRY/DRUG EFFECTS/ GENETICS/ULTRASTRUCTURE *Gene Products, gag/ANTAGONISTS & INHIB/CHEMISTRY/DRUG EFFECTS/ GENETICS/ULTRASTRUCTURE *Gene Products, pol/ANTAGONISTS & INHIB/CHEMISTRY/DRUG EFFECTS/ GENETICS/ULTRASTRUCTURE Human *HIV/CHEMISTRY/GROWTH & DEVELOPMENT/GENETICS/PHYSIOLOGY/ ULTRASTRUCTURE HIV Infections/CONGENITAL/MICROBIOLOGY/PREVENTION & CONTROL/ TRANSMISSION Infant, Newborn Molecular Biology Pregnancy Pregnancy Complications, Infectious/MICROBIOLOGY/PREVENTION & CONTROL Regulatory Sequences, Nucleic Acid Time Factors Trans-Activators/CHEMISTRY/GENETICS/ULTRASTRUCTURE Transcription, Genetic *Viral Regulatory Proteins/CHEMISTRY/DRUG EFFECTS/GENETICS/ ULTRASTRUCTURE Virion/CHEMISTRY/GROWTH & DEVELOPMENT/GENETICS/PHYSIOLOGY/ ULTRASTRUCTURE Virus Integration Virus Replication JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).