Document 0894
 DOCN  M9470894
 TI    Prevalence of lymphopenia in children with AIDS.
 DT    9409
 AU    Suarez AD; Rao SP; Miller ST; Division of Hematology and Oncology,
       Children's Medical Center,; Brooklyn, New York.
 SO    Clin Pediatr (Phila). 1994 Apr;33(4):204-8. Unique Identifier : AIDSLINE
       MED/94282987
 AB    Hematologic abnormalities, such as anemia, neutropenia, lymphopenia, and
       thrombocytopenia, are frequently observed in patients with acquired
       immunodeficiency syndrome (AIDS). While lymphopenia has been noted in up
       to 80% of adults, only 50% of children with AIDS are reported to be
       lymphopenic. We reviewed the blood counts of hospitalized children with
       AIDS to determine the frequency of lymphopenia and other hematologic
       abnormalities. Seventy-four children with AIDS (ages 4 months to 9.5
       years) were admitted to Kings County Hospital Center (Brooklyn, New
       York) from January 1990 to March 1991; data consisted of 709 CBCs (range
       one to 39, median 11) from 176 admissions (range one to 15). In some
       patients admitted during the study period, charts from previous
       admissions were reviewed. Anemia (Hb less than than third percentile for
       age) was noted in 68 of 74 (92%) patients. Leukopenia (WBC less than
       4000/mm3) was noted in 32 of 74 (43%) patients. Lymphopenia (lymphocyte
       counts below normal for age) was seen in 59 of 74 (78%) patients; of
       these, more than half (31 of 59) had persistently low absolute
       lymphocyte counts. Thrombocytopenia (platelet count less than
       150,000/mm3) was seen in 20 of 74 (27%) and was found in four of eight
       patients who expired. Pancytopenia was seen in nine of 74 (12%)
       patients. Progression of hematologic abnormalities with anemia followed
       by lymphopenia, thrombocytopenia, and finally leukopenia was
       demonstrated in 22 patients. This review shows a prevalence of
       hematologic abnormalities that is similar to those of previous reports
       in children except for a considerably higher prevalence of lymphopenia.
       As expected, lymphopenia was a marker for disease progression.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS
       Anemia/BLOOD/EPIDEMIOLOGY  Child  Child, Preschool  Human  Incidence
       Infant  Lymphopenia/BLOOD/COMPLICATIONS/*EPIDEMIOLOGY  Prevalence
       Retrospective Studies  Thrombocytopenia/BLOOD/EPIDEMIOLOGY  JOURNAL
       ARTICLE  REVIEW  REVIEW, MULTICASE

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