Document 0897
 DOCN  M9470897
 TI    Mutations in the coding region of c-MYC in AIDS-associated and other
       aggressive lymphomas.
 DT    9409
 AU    Clark HM; Yano T; Otsuki T; Jaffe ES; Shibata D; Raffeld M;
       Hematopathology Section, National Cancer Institute, NIH,; Bethesda, MD
       20892.
 SO    Cancer Res. 1994 Jul 1;54(13):3383-6. Unique Identifier : AIDSLINE
       MED/94282742
 AB    Our previous studies of the translocated MYC gene in Burkitt's lymphoma
       showed the existence of clustered somatic mutations located in the
       transcriptional activation domain. We now report that aggressive
       lymphomas arising in the acquired immunodeficiency syndrome (AIDS)
       contain similar mutations and that the presence of mutations is
       correlated with the rearrangement of the oncogene. Mutations were also
       found in other de novo non-AIDS, non-Burkitt's aggressive lymphomas with
       MYC rearrangements. An unusual asparagine to serine mutation at codon 11
       was identified in several transformed follicular lymphomas without MYC
       rearrangement but not in normal tissues from patients with this
       mutation. These findings indicate that AIDS-associated and other de novo
       aggressive lymphomas with the MYC gene rearrangement are subject to the
       same mutation and selection process that affects Burkitt's lymphomas.
 DE    Amino Acid Sequence  Genes, myc/*GENETICS  Human  Lymphoma,
       AIDS-Related/*GENETICS  Lymphoma, Large-Cell, Diffuse/GENETICS
       Lymphoma, Large-Cell, Immunoblastic/GENETICS  Lymphoma,
       Non-Hodgkin's/*GENETICS  Lymphoma, Small-Cell/GENETICS  Molecular
       Sequence Data  Point Mutation/*GENETICS  JOURNAL ARTICLE

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