Document 0905
 DOCN  M9470905
 TI    Late renal allograft failure secondary to thrombotic
       microangiopathy-human immunodeficiency virus nephropathy.
 DT    9409
 AU    Frem GJ; Rennke HG; Sayegh MH; Department of Medicine, Brigham and
       Women's Hospital, Boston, MA; 02115.
 SO    J Am Soc Nephrol. 1994 Mar;4(9):1643-8. Unique Identifier : AIDSLINE
       MED/94281578
 AB    The case of a renal transplant recipient with a known history of iv drug
       abuse but unknown human immunodeficiency virus (HIV) status who presents
       after having a stable renal allograft function for 4 yr, with
       acute/subacute advanced renal failure, nephrotic syndrome, and
       hypertension, as well as clinical and histologic findings of thrombotic
       microangiopathy, is reported. He was subsequently found to have a
       positive serology for HIV-1 with a low CD4 count but no clinical
       manifestations of the acquired immunodeficiency syndrome. He was treated
       conservatively with zidovudine (AZT). The patient never regained graft
       function and was ultimately discharged from the hospital on maintenance
       dialytic therapy. This is, to our knowledge, the first report of
       thrombotic microangiopathy in an HIV-1-infected patient presenting late
       in the course as acute/subacute renal allograft failure.
 DE    Adult  Azathioprine/THERAPEUTIC USE  AIDS-Associated
       Nephropathy/*COMPLICATIONS  Case Report  Cyclosporine/ADVERSE
       EFFECTS/THERAPEUTIC USE  Graft Rejection/*ETIOLOGY  Human
       Hypertension/COMPLICATIONS  Kidney Glomerulus/PATHOLOGY  *Kidney
       Transplantation  Male  Microcirculation  Thrombosis/CHEMICALLY
       INDUCED/*COMPLICATIONS  Time Factors  Transplantation, Homologous
       JOURNAL ARTICLE

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