Document 0916
 DOCN  M9470916
 TI    Paromomycin: an effective treatment for cryptosporidial diarrhea in
       patients with AIDS.
 DT    9409
 AU    Bissuel F; Cotte L; Rabodonirina M; Rougier P; Piens MA; Trepo C; AIDS
       and Hepatogastroenterology Unit, Hopital de l'Hotel-Dieu,; Lyon, France.
 SO    Clin Infect Dis. 1994 Mar;18(3):447-9. Unique Identifier : AIDSLINE
       MED/94281432
 AB    Cryptosporidiosis is a common cause of diarrhea in patients with AIDS
       but remains one of the most challenging AIDS-related conditions to
       treat. We therefore carried out an open, uncontrolled, prospective study
       to evaluate the efficacy of oral paromomycin for the treatment of
       chronic diarrhea due to Cryptosporidium in 24 successive patients
       infected with human immunodeficiency virus. Twenty-two of the 24
       patients responded clinically, with complete remission occurring in 18
       cases and marked reduction of the diarrhea occurring in four. Clearance
       of cryptosporidia from stools and/or intestinal biopsy specimens
       occurred within 2-4 weeks. Furthermore, all 18 patients who achieved
       complete remission gained weight. Ten patients relapsed either during
       administration of maintenance therapy or after discontinuation of
       treatment, but diarrhea resolved again after increasing or restarting
       paromomycin therapy in all but two. Paromomycin appeared to be an active
       and well-tolerated treatment for cryptosporidiosis in patients with
       AIDS. Efficacy is dose-related, and continuous maintenance therapy is
       required to prevent relapses. These data suggest that paromomycin might
       be given as first-line therapy in AIDS-related cryptosporidiosis, but
       this should be confirmed by the findings of a controlled, randomized
       trial.
 DE    Administration, Oral  Adult  Animal  AIDS-Related Opportunistic
       Infections/*COMPLICATIONS/*DRUG  THERAPY/PARASITOLOGY
       Cryptosporidiosis/*COMPLICATIONS/*DRUG THERAPY/PARASITOLOGY
       Cryptosporidium/ISOLATION & PURIF  Diarrhea/*COMPLICATIONS/*DRUG
       THERAPY/PARASITOLOGY  Human  Male  Middle Age
       Paromomycin/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE  Prospective
       Studies  Recurrence  CLINICAL TRIAL  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).