Document 0917
 DOCN  M9470917
 TI    Mycobacterium kansasii among patients infected with human
       immunodeficiency virus in Kansas City. Kansas City AIDS Research
       Consortium.
 DT    9409
 AU    Bamberger DM; Driks MR; Gupta MR; O'Connor MC; Jost PM; Neihart RE;
       McKinsey DS; Moore LA; University of Missouri-Kansas City School of
       Medicine, Kansas; City, Missouri.
 SO    Clin Infect Dis. 1994 Mar;18(3):395-400. Unique Identifier : AIDSLINE
       MED/94281421
 AB    Previous reports of infection due to Mycobacterium kansasii among
       patients infected with human immunodeficiency virus (HIV) have
       conflicted with regard to the significance of the isolate; the clinical,
       radiographic, and laboratory features of the disease; and the response
       to therapy. To clarify the spectrum of M. kansasii infection in this
       population, we conducted a retrospective study of 35 patients.
       Twenty-eight of these patients were believed to have disease due to M.
       kansasii, while the remaining seven patients were probably colonized
       with the organism. All but two patients presented with advanced HIV
       infection; the median CD4 cell count was 12/microL. Most patients with
       pulmonary disease presented with fever, cough, and dyspnea, but only
       eight of these 22 patients had radiographic findings of either pulmonary
       cavitation or predominantly upper-lobe disease. Ten patients had M.
       kansasii isolated from blood or bone marrow. The majority of patients
       with pulmonary or disseminated disease responded to therapy. However, 11
       patients died either before mycobacterial infection was diagnosed or
       early in the course of treatment, and two had a relapse of infection
       during therapy.
 DE    Antibiotics/THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/*COMPLICATIONS/DRUG THERAPY/  *EPIDEMIOLOGY  Human
       Kansas/EPIDEMIOLOGY  Mycobacterium Infections,
       Atypical/*COMPLICATIONS/DRUG THERAPY/  *EPIDEMIOLOGY  Prognosis
       Retrospective Studies  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).