Document 0920
 DOCN  M9470920
 TI    Nocardiosis in 30 patients with advanced human immunodeficiency virus
       infection: clinical features and outcome.
 DT    9409
 AU    Uttamchandani RB; Daikos GL; Reyes RR; Fischl MA; Dickinson GM;
       Yamaguchi E; Kramer MR; Department of Medicine, University of Miami
       School of Medicine,; Florida.
 SO    Clin Infect Dis. 1994 Mar;18(3):348-53. Unique Identifier : AIDSLINE
       MED/94281413
 AB    A total of 30 patients (aged 6-56 years) with nocardiosis and infection
       due to human immunodeficiency virus type 1 (HIV-1) were identified in
       our institution between January 1985 and June 1989. Eighteen patients
       had an AIDS-defining illness before or concurrently with nocardiosis.
       The mean CD4 lymphocyte count was 109/mm3. Pulmonary nocardiosis in 21
       patients, extra-pulmonary nocardiosis in 8, and pulmonary and
       extrapulmonary nocardiosis in 1 patient was diagnosed. Chest radiographs
       showed alveolar patterns of infiltrates in 14 patients, reticulonodular
       patterns in 2, mixed alveolar and reticulonodular patterns in 6,
       cavitation in 4, and pleural effusion in 3. Of 27 patients treated, the
       conditions of 22 improved, but the extensive disease in 5 progressed.
       For 14 patients, recurrence was rapid after their treatment was
       discontinued. Nocardiosis caused or contributed to the death of 19
       patients; in six patients, there was no evidence of nocardial infection
       at death. Nocardiosis can be a fatal complication of advanced HIV-1
       disease. Delayed diagnosis, extensive disease, and early discontinuation
       of treatment were associated with poor outcome.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Adolescence  Adult
       Antibiotics/THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/*COMPLICATIONS/DIAGNOSIS/  DRUG THERAPY  Child  Female  Human
       HIV Infections/*COMPLICATIONS  *HIV-1  Male  Middle Age  Nocardia
       Infections/*COMPLICATIONS/DIAGNOSIS/DRUG THERAPY  Prognosis  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).