Document 0926
 DOCN  M9470926
 TI    Serum antibody for somatostatin-14 and prodynorphin 209-240 in patients
       with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease,
       multiple sclerosis, and advanced HIV infection.
 DT    9409
 AU    Roy BF; Benkelfat C; Hill JL; Pierce PF; Dauphin MM; Kelly TM;
       Sunderland T; Weinberger DR; Breslin N; Psychiatry Service, Veterans
       Affairs Medical Center, Albany, NY; 12208.
 SO    Biol Psychiatry. 1994 Mar 1;35(5):335-44. Unique Identifier : AIDSLINE
       MED/94281398
 AB    Patients with obsessive-compulsive disorder (OCD) demonstrated
       significant levels of antibody for somatostatin-28, its C-terminal
       fragment somatostatin-14, and prodynorphin. In contrast there were lower
       levels of reactivity for somatostatin-28(1-14) (the N-terminal fragment
       of somatostatin-28) and negligible reactivity for several other peptides
       including beta-endorphin and corticotropin. Healthy volunteers and
       disease controls [schizophrenia, Alzheimer's disease, multiple
       sclerosis, and subjects with advanced human immunodeficiency virus (HIV)
       infection] exhibited negligible reactivity. These data raise the
       consideration of an autoimmune mechanism for some OCD.
 DE    Adult  Alzheimer's Disease/*IMMUNOLOGY  Antibodies/*BLOOD/IMMUNOLOGY
       Antibody Formation/IMMUNOLOGY  Autoimmunity  Binding, Competitive
       Enkephalins/*IMMUNOLOGY  Enzyme-Linked Immunosorbent Assay  Female
       Human  HIV Seropositivity/*IMMUNOLOGY  Male  Multiple
       Sclerosis/*IMMUNOLOGY  Obsessive-Compulsive Disorder/*IMMUNOLOGY
       Protein Precursors/*IMMUNOLOGY  Schizophrenia/*IMMUNOLOGY
       Somatostatin/*IMMUNOLOGY  Support, U.S. Gov't, Non-P.H.S.  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).