Document 0935
 DOCN  M9470935
 TI    [Campylobacter jejuni and HIV infection]
 DT    9409
 AU    Martinez RM; Figueras MP; Ramos C; Sanjuan F; Aguirre JM; Servicio de
       Medicina Interna, Hospital Miguel Servet, Zaragoza.
 SO    Enferm Infecc Microbiol Clin. 1994 Feb;12(2):90-4. Unique Identifier :
       AIDSLINE MED/94281304
 AB    OBJECTIVE: To evaluate the characteristics of the Campylobacter jejuni
       infection in HIV positive patients. DESIGN: We report all cases appeared
       in our hospital between September 1991 and October 1992 with: HIV
       infection, chronic diarrhoea and C. jejuni in stool culture.
       Epidemiologic factors, other opportunist infections, immunologic
       situation, clinical symptomatology, antibiotic sensitivity and evolution
       are recorded. RESULTS: Six patients, 4 men and 2 women, with an average
       age of 38 years were recorded. They have different risk factors (drug
       abusers, sexual behaviour and haemophilia). Chronic liver disease and
       other opportunist infections of the gastrointestinal tract were the most
       important facts in past history. CD4 count were directly related with
       the severity of the illness. Quantitative or qualitative disorders of B
       lymphocytes or immunoglobulins were not found. All of term suffered from
       chronic diarrhoea with fever in four of them and bacteremia in 2
       patients. First generation cephalosporins resistance in one occasion. A
       good evolution occurred in 3 patients, another had a relapse and
       bacteremia appeared in 2 patients whose CD4 count were lower of 100/mm3,
       have AST, ALT changes and other concomitant gastrointestinal infections.
       CONCLUSION: C. jejuni infection of the gastrointestinal tract results in
       chronic diarrhoea with a higher incidence than expected in HIV positive
       patients. The severity is directly related with CD4 count, and the
       existence of concomitants infections of the gastrointestinal tract or
       chronic liver disease. Antibiotic resistance to macrolide is possible,
       especially in chronic and severe forms.
 DE    Adult  AIDS-Related Opportunistic Infections/IMMUNOLOGY/*MICROBIOLOGY
       Campylobacter jejuni/DRUG EFFECTS/*ISOLATION & PURIF  *Campylobacter
       Infections/COMPLICATIONS/IMMUNOLOGY/MICROBIOLOGY
       Diarrhea/IMMUNOLOGY/*MICROBIOLOGY  English Abstract  Female  Hepatitis,
       Viral, Human/COMPLICATIONS  Human  HIV Infections/COMPLICATIONS
       Leukocyte Count  Male  Risk Factors  T4 Lymphocytes  JOURNAL ARTICLE

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