Document 0937
 DOCN  M9470937
 TI    Expression of fos proto-oncogene product by monoclonal antibody FO-120
       in smouldering adult T-cell leukaemia (ATL).
 DT    9409
 AU    Iwahashi M; Otsuka M; Shimotakahara S; Uozumi K; Hanada S; Arima T;
       Matsumoto M; Second Department of Internal Medicine, Oita Medical
       University,; Japan.
 SO    Br J Haematol. 1994 Jan;86(1):193-4. Unique Identifier : AIDSLINE
       MED/94281077
 AB    We investigated the expression of c-fos gene product in peripheral blood
       mononuclear cells of patients with smouldering adult T-cell leukaemia
       (ATL) and healthy human T-lymphotropic virus type-I (HTLV-I) carriers by
       an immunofluorescence assay, using a mouse monoclonal antibody (FO-120)
       specific for fos gene product. Peripheral blood mononuclear cells
       derived from healthy HTLV-I carriers were rarely positive for FO-120,
       less than 2% of the cells weakly reacted with FO-120, whereas positive
       cells were detected in more than about 10% of cells from patients with
       smouldering ATL. FO-120 appears to be a useful tool for detecting
       smouldering ATL in asymptomatic HTLV-I infected people without using
       molecular techniques.
 DE    Adult  Aged  Aged, 80 and over  Antibodies, Monoclonal  Carrier
       State/BLOOD/DIAGNOSIS  Diagnosis, Differential  Female  Gene Expression
       Human  HTLV-I Infections/BLOOD/*DIAGNOSIS  Leukemia,
       T-Cell/BLOOD/*DIAGNOSIS  Male  Middle Age  Neoplasm Proteins/*BLOOD
       Proto-Oncogene Proteins c-fos/*BLOOD  Tumor Markers, Biological/*BLOOD
       JOURNAL ARTICLE

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