Document 0944
 DOCN  M9470944
 TI    Isoprinosine stimulates granulocyte chemiluminescence and inhibits
       monocyte chemiluminescence in vitro.
 DT    9409
 AU    Flo RW; Naess A; Albrektsen G; Solberg CO; Medical Department B,
       Haukeland Hospital, University of Bergen,; Norway.
 SO    APMIS. 1994 Apr;102(4):249-54. Unique Identifier : AIDSLINE MED/94280808
 AB    Isoprinosine may delay disease progression in human immunodeficiency
       virus infection, presumably through modulation of lymphocyte function.
       However, the influence of isoprinosine on phagocyte function is largely
       unknown. This study describes the effects of isoprinosine and
       azidothymidine on phagocyte chemiluminescence and migration. Incubation
       with isoprinosine concentrations of 250 micrograms/ml and above
       increased the chemiluminescence of granulocytes. Random migration of
       granulocytes was decreased at isoprinosine concentrations of 50
       micrograms/ml and higher, but chemotaxis was not affected.
       Azidothymidine exerted no effect on the chemiluminescence or migration
       of granulocytes. For monocytes, luminol-enhanced chemiluminescence was
       reduced at isoprinosine concentrations of 250 micrograms/ml and above,
       whereas migration was not affected. These findings suggest that the
       immunomodulatory properties of isoprinosine may extend to phagocytic
       cells. This may be of significance in the treatment of immunodeficiency
       states.
 DE    Cell Movement/DRUG EFFECTS  *Chemiluminescence  Chemotaxis,
       Leukocyte/DRUG EFFECTS  Granulocytes/*CYTOLOGY/DRUG EFFECTS  Human  In
       Vitro  Isoprinosine/*PHARMACOLOGY  Monocytes/*CYTOLOGY/DRUG EFFECTS
       Support, Non-U.S. Gov't  Zidovudine/PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).