Document 0983
 DOCN  M9470983
 TI    Predictive value of repeated measurements of CD4 lymphocyte counts on
       progression to AIDS.
 DT    9409
 AU    Boutitie F; Pocock SJ; Medical Statistics Unit, London School of Hygiene
       and Tropical; Medicine, UK.
 SO    AIDS. 1994 Jan;8(1):35-41. Unique Identifier : AIDSLINE MED/94280702
 AB    OBJECTIVE: Description of the relationship between repeated measurements
       of CD4 lymphocyte count and development of AIDS in asymptomatic
       HIV-infected patients. DESIGN: Repeated measurements of CD4 lymphocyte
       counts over an AIDS-free period in asymptomatic HIV-infected patients,
       and follow-up of the cohort to record subsequent clinical progression to
       AIDS. METHODS: The cohort was studied in a double-blind randomized
       clinical trial. CD4 lymphocyte counts were measured on three occasions
       over 8 months in 851 patients. RESULTS: Eighty subsequent clinical
       progressions to AIDS were recorded during a median follow-up period of
       15.3 months. Each of the three measurements of CD4 lymphocyte count were
       separately predictive of subsequent progression to AIDS. However, when
       the three measurements were included simultaneously in a predictive
       model only the last measurement showed a significant predictive value.
       Change in individual CD4 count was also related to the risk of
       developing AIDS, but was no longer significant when the most recent
       measurement was included in the model. CONCLUSION: These results
       indicate the closeness of the relationship between the actual state of
       the immune system and subsequent progression to AIDS.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/PHYSIOPATHOLOGY  Adult
       Biological Markers  Cohort Studies  Double-Blind Method  Female  Human
       Leukocyte Count  Male  Predictive Value of Tests  Support, Non-U.S.
       Gov't  *T4 Lymphocytes  CLINICAL TRIAL  JOURNAL ARTICLE  RANDOMIZED
       CONTROLLED TRIAL

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