Document 1033
 DOCN  M9471033
 TI    Developing and implementing guidelines to promote appropriate use of
       fluconazole therapy in an AIDS clinic.
 DT    9409
 AU    Anassi EO; Egbunike IG; Akpaffiong MJ; Ike EN; Cate TR; Texas Southern
       University, College of Pharmacy and Health; Sciences, Houston.
 SO    Hosp Pharm. 1994 Jun;29(6):576-8, 581-2, 585-6. Unique Identifier :
       AIDSLINE AHA/94266663
 AB    A retrospective and concurrent drug use evaluation for fluconazole in an
       outpatient AIDS clinic is described. Eighty-eight patient charts were
       reviewed in the evaluation during an 8-week period, and 72 patients were
       studied in the concurrent evaluation for a period of 5 weeks. A set of
       preestablished fluconazole usage and dosing guidelines was developed by
       the clinical pharmacist and the chairman of the antimicrobial
       subcommittee/chief of infectious disease and approved by the pharmacy
       and therapeutics committee. Patients who did not meet these guidelines
       were those being treated for oropharyngeal and esophageal candidiasis.
       The use of fluconazole was not indicated in 43 of 54 (80%) patients in
       retrospective evaluation and 31 of 39 (79.5%) patients before clinical
       pharmacist intervention in concurrent study. If guidelines had been
       followed during the retrospective evaluation, cost savings would have
       been $295 per day, which adds up to $16,520 for 8 weeks. In the actual
       evaluation, the cost savings with pharmacist intervention for 5 weeks
       was $5,460, which can be extrapolated to annual cost savings of $65,520.
 DE    AIDS-Related Opportunistic Infections/*DRUG THERAPY  Concurrent Review
       Cost Savings/STATISTICS & NUMER DATA  Drug Costs/*STATISTICS & NUMER
       DATA  *Drug Utilization Review/ECONOMICS
       Fluconazole/*ECONOMICS/*THERAPEUTIC USE  Human  Outpatient Clinics,
       Hospital/ECONOMICS/*STANDARDS  Patient Care Team  Pharmacy Service,
       Hospital/ECONOMICS/*STANDARDS  *Practice Guidelines  Retrospective
       Studies  Texas  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).