Document 1074
 DOCN  M9471074
 TI    Dietary carotenoids, cigarette smoking and Kaposi's sarcoma in the San
       Francisco Men's Health Study.
 DT    9409
 AU    Duncan DM; Univ. of California, Berkeley
 SO    Diss Abstr Int [B]; 53(9):4596 1993. Unique Identifier : AIDSLINE
       ICDB/94690808
 AB    This study utilized data from the San Francisco Men's Health Study
       (SFMHS) to explore the relationship between dietary intake and
       subsequent development of Kaposi's sarcoma (KS) in a cohort of men at
       high risk for acquired immunodeficiency syndrome (AIDS). The SFMHS is a
       prospective study observing the natural history of AIDS conducted on a
       probability sample of over 1000 men aged 25 to 54 yr, who resided in the
       census tracts of San Francisco with the highest cumulative incidence of
       AIDS through December 1983. In 1984, dietary information was obtained
       during the first cycle of data collection, using the Health Habits and
       History Questionnaire (HHHQ), a food frequency questionnaire developed
       by the National Cancer Institute (NCI). Univariate analysis revealed a
       statistically significant relationship between energy-adjusted tertiles
       of carotenoid intake and KS development, with the lowest tertile of
       intake increasing the risk of KS, relative risk (RR) = 2.91. After
       adjusting for covariates that remained significant in multiple logistic
       regression analysis (college education, cigarette smoking and poor
       health at study baseline), the risk of KS appeared to be highly
       inversely associated with carotenoid intake (odds ratio for lowest
       tertile = 4.06, 95% confidence interval (Cl) 1.39-11.89, odds ratio for
       middle tertile = 3.01, 95% Cl 1.03-8.85, test for trend p-value = 0.02,
       and Likelihood Ratio Test chi square = 7.80, p-value = 0.020). No other
       nutrient was significantly associated with KS development in
       multivariate analysis. Stratification by smoking status showed the
       relationship between a low carotenoid intake and an increased risk of KS
       to be in smokers only (for smokers, odds ratio for lowest tertile =
       7.67, 95% Cl 1.68-35.09, odds ratio for middle tertile = 3.25, 95% Cl
       0.66-15.88, test for trend p-value = 0.05, and Likelihood Ratio Test chi
       square = 8.48, p-value = 0.014). (Full text available from University
       Microfilms International, Ann Arbor, MI, as Order No. AAD92-28635.)
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/EPIDEMIOLOGY  Adult
       Carotenoids/*THERAPEUTIC USE  Cohort Studies  *Diet  Human  Male  Middle
       Age  Odds Ratio  Questionnaires  Regression Analysis  San
       Francisco/EPIDEMIOLOGY  Sarcoma, Kaposi's/DIET THERAPY/*ETIOLOGY
       *Smoking  THESIS

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).