Document 0006
 DOCN  M9480006
 TI    Placental cryptococcosis in a mother with systemic lupus erythematosus.
 DT    9410
 AU    Molnar-Nadasdy G; Haesly I; Reed J; Altshuler G; Department of
       Pathology, University of Oklahoma Health Sciences; Center, Oklahoma
       City.
 SO    Arch Pathol Lab Med. 1994 Jul;118(7):757-9. Unique Identifier : AIDSLINE
       MED/94296232
 AB    There are many pregnant mothers who have acquired immunodeficiency
       syndrome or who require immunosuppressive therapy for sundry reasons.
       Despite this, we have been able to find only one English-language report
       of placental cryptococcosis. We have had an opportunity to treat a
       pregnant mother who suffered from cryptococcal meningitis that
       complicated steroid treatment for lupus erythematosus. At 31 weeks'
       gestation, fetal distress necessitated delivery by cesarean section. The
       placenta had focally abundant intervillous and perivillous cryptococcal
       yeast cells, but there was no chorioamnionitis or villitis. Although
       there were no clinical or placental signs of transplacental infection,
       immunohistochemical labeling of villous stromal cells showed a
       conspicuously increased number of fetal macrophages.
 DE    Adult  Case Report  Cryptococcosis/IMMUNOLOGY/*PATHOLOGY  Female  Human
       Immunosuppressive Agents/THERAPEUTIC USE  Lupus Erythematosus,
       Systemic/*COMPLICATIONS/DRUG THERAPY  Meningitis,
       Cryptococcal/COMPLICATIONS  Opportunistic Infections/PATHOLOGY  Placenta
       Diseases/*MICROBIOLOGY/PATHOLOGY  Pregnancy  *Pregnancy Complications
       Pregnancy Complications, Infectious/MICROBIOLOGY/*PATHOLOGY  JOURNAL
       ARTICLE

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