Document 0008
 DOCN  M9480008
 TI    CD8+ polylobated T-cell leukemia/lymphoma. A case report with
       immunophenotypic, ultrastructural, gene rearrangement, karyotypic, and
       DNA content analysis and autopsy description.
 DT    9410
 AU    Friedman HD; Hutchison RE; Smith JR; Gonchoroff NJ; Stein CK; Poiesz BJ;
       Department of Pathology and Laboratory Medicine, Syracuse, NY; 13210.
 SO    Arch Pathol Lab Med. 1994 Jul;118(7):722-7. Unique Identifier : AIDSLINE
       MED/94296223
 AB    Polylobated lymphoma is a morphologic variant of malignant lymphoma
       characterized by large pleomorphic neoplastic cells with polylobated
       nuclei. We report an unusual case in a 57-year-old man with a 9-year
       history of an antecedent low-grade peripheral T-cell lymphoma with
       dermal involvement. The polylobated lymphoma expressed the CD2, 8, 45,
       and DR surface antigens and had a clonally rearranged T-cell receptor
       beta-chain gene. The DNA content analysis indicated that most of the
       neoplasm was DNA diploid and tetraploid, with a high S phase.
       Cytogenetic analysis demonstrated the presence of a clone with an
       abnormal karyotype 45, X, -Y, -1, -10, -10, -17, -19, +5 mar. Serology
       and polymerase chain reaction analysis showed no evidence of retroviral
       infection (human immunodeficiency virus types 1 and 2 and human T-cell
       lymphotropic virus types I and II). We review the literature on
       polylobated T-cell lymphoma.
 DE    Antigens, CD8/*ANALYSIS  Case Report  DNA, Neoplasm/ANALYSIS  Gene
       Rearrangement  Human  Immunohistochemistry  Immunophenotyping
       Karyotyping  Lymphoma, T-Cell/GENETICS/IMMUNOLOGY/*PATHOLOGY  Male
       Microscopy, Electron  Middle Age  JOURNAL ARTICLE  REVIEW  REVIEW OF
       REPORTED CASES

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