Document 0009
 DOCN  M9480009
 TI    [Acute Staphylococcus aureus myocarditis in AIDS. 2 cases]
 DT    9410
 AU    Hofman P; Michiels JF; Rosenthal E; Tran AT; Taillan B; Ferrari E;
       Loubiere R; Service d'anatomie pathologique, hopital Pasteur, Nice.
 SO    Arch Mal Coeur Vaiss. 1993 Dec;86(12):1765-8. Unique Identifier :
       AIDSLINE MED/94296193
 AB    The authors report two cases of acute myocarditis due to Staphylococcus
       aureus in patients with AIDS. There was no history of opportunist
       infections in either case but the CD4 lymphocyte levels were very low.
       The myocarditis caused acute cardiac failure and death. Histological
       examination showed microabscesses filled with Gram positive cocci
       throughout the myocardium. Bacteriological studies identified the
       Staphylococcus aureus. Staphylococcus aureus myocarditis without
       endocardial or pericardial involvement is very rare. It is the result of
       septic emboli in the cardiac microcirculation. Bacterial myocarditis has
       rarely been diagnosed in HIV positive patients. Both our cases featured
       severe cell-mediated immunodeficiency without associated neutropaenia.
       The decreased bactericidal activity of the neutrophil polynuclears
       and/or a deficit in the immunity mediated by the B-cell lymphocytes in
       AIDS could explain the lethal septic complications observed in our two
       cases.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Acute Disease  Adult
       AIDS-Related Opportunistic Infections/*COMPLICATIONS  Case Report
       CD4-CD8 Ratio  English Abstract  Fatal Outcome  Female  Heart
       Hypertrophy/ETIOLOGY  Human  Male
       Myocarditis/*ETIOLOGY/MICROBIOLOGY/PATHOLOGY  Staphylococcal
       Infections/*COMPLICATIONS  *Staphylococcus aureus  JOURNAL ARTICLE

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