Document 0015
 DOCN  M9480015
 TI    American cutaneous leishmaniasis: in situ characterization of the
       cellular immune response with time.
 DT    9410
 AU    Lima HC; Vasconcelos AW; David JR; Lerner EA; Nucleo de Medicina
       Tropical, Universidade Federal do Ceara,; Fortalez, Brazil.
 SO    Am J Trop Med Hyg. 1994 Jun;50(6):743-7. Unique Identifier : AIDSLINE
       MED/94295850
 AB    The cellular nature of the infiltrate in the skin of patients with
       American cutaneous leishmaniasis was characterized by
       immunohistochemistry. The study population consisted of patients in
       Ceara, Brazil, an area where Leishmania braziliensis is endemic.
       Biopsies were taken from lesions present for 0.5-4 months duration and
       sections were stained with antibodies to T cells, T cell subsets, B
       cells, and macrophage markers to quantitate these cell types. The T
       cells accounted for 37.0 +/- 7.6% (mean +/- SD) of the infiltrate. The
       average percentages of CD4- and CD8-positive T cells were similar to
       each other, 20.4 +/- 9.0% and 19.9 +/- 6.7%, respectively. Interleukin-2
       receptor-positive cells and B cells were infrequent, 3.7 +/- 3.0% and
       2.3 +/- 3.1%, respectively. When the relationship between the age of the
       lesion at biopsy and the cellular phenotype was examined, it was noted
       that the percentage of positive cells remained fixed for all cell types
       except for that of gamma delta cells, which decreased with time. It is
       likely that gamma delta T cells are important in the early phase of the
       immune response to L. braziliensis and may, in general, be important in
       the early immune response of granulomatous diseases.
 DE    Adolescence  Adult  Animal  Antibodies, Monoclonal/IMMUNOLOGY  Biopsy
       Child  Child, Preschool  CD4-CD8 Ratio  Female  Human  Immunity,
       Cellular  Immunoenzyme Techniques  Immunophenotyping  Infant  Leishmania
       braziliensis/*IMMUNOLOGY/ISOLATION & PURIF  Leishmaniasis,
       Cutaneous/*IMMUNOLOGY  Male  Middle Age
       Skin/*IMMUNOLOGY/PATHOLOGY/PARASITOLOGY  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).