Document 0016
 DOCN  M9480016
 TI    A quantitative and cartographic study of retinal microvasculopathy in
       acquired immunodeficiency syndrome.
 DT    9410
 AU    Glasgow BJ; Weisberger AK; Jules Stein Eye Institute, Los Angeles, CA
       90024.
 SO    Am J Ophthalmol. 1994 Jul 15;118(1):46-56. Unique Identifier : AIDSLINE
       MED/94295622
 AB    We quantified the retinal microvascular abnormalities in 57 eyes from
       autopsy patients with the acquired immunodeficiency syndrome (AIDS) and
       in 24 eyes from gender- and age-matched control subjects. We related
       retinal vascular changes to the topography of cytomegalovirus retinitis.
       Analysis of retinal trypsin digests revealed more vascular attenuation
       (P = .005), increased ratio of endothelial cells to pericytes (P =
       .001), and more microaneurysms (P = .02) in eyes of AIDS patients
       without cytomegalovirus retinitis than in those of control subjects.
       Cytomegalovirus retinitis was frequently bilateral, extensive, and
       distributed along blood vessels. Peripheral retinitis was more frequent
       than macular infection. Lymphocytes aggregated focally in arterioles,
       venules, and capillaries leading to areas infected with cytomegalovirus.
       Acquired immunodeficiency syndrome microvasculopathy occurs in the
       absence of cytomegalovirus retinitis and is not accounted for by
       immunosuppression alone. The location and character of these vascular
       changes in AIDS indicate an ischemic pathogenesis. In AIDS patients with
       cytomegalovirus retinitis, the vascular changes are more profound and
       include capillary destruction.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  AIDS-Related
       Opportunistic Infections/PATHOLOGY  Capillaries/PATHOLOGY
       Cytomegalovirus Retinitis/ETIOLOGY/PATHOLOGY  Endothelium,
       Vascular/PATHOLOGY  Female  Human  Male  Retinal
       Diseases/COMPLICATIONS/PATHOLOGY  Retinal Vessels/*PATHOLOGY  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).