Document 0036
 DOCN  M9480036
 TI    Transfusion transmission of retroviruses: human T-lymphotropic virus
       types I and II compared with human immunodeficiency virus type 1.
 DT    9410
 AU    Donegan E; Lee H; Operskalski EA; Shaw GM; Kleinman SH; Busch MP;
       Stevens CE; Schiff ER; Nowicki MJ; Hollingsworth CG; et al; University
       of California, San Francisco.
 SO    Transfusion. 1994 Jun;34(6):478-83. Unique Identifier : AIDSLINE
       MED/94295061
 AB    BACKGROUND: The incidence of transfusion transmission of human
       T-lymphotropic virus type I (HTLV-I) and HTLV type II (HTLV-II) has not
       been compared directly or to that of human immunodeficiency virus type 1
       (HIV-1). The effects of refrigerator storage of the blood component on
       infectivity of the viruses needs definition. STUDY DESIGN AND METHODS:
       The circumstances influencing the transmission of HTLV-I, HTLV-II, and
       HIV-1 via blood of donors whose sera were stored in a repository and who
       were retrospectively documented as having been infected at blood
       donation were examined. Confirmation and typing of anti-HTLV positivity
       in donors and recipients used polymerase chain reaction, supplemented by
       specific peptide testing. RESULTS: Overall, 27 percent (26/95) of the
       recipients of blood components from anti-HTLV-I- and -II-positive donors
       became infected (9 with HTLV-I and 17 with HTLV-II). No recipients of
       acellular blood components became infected with HTLV-I or -II. There was
       no probable transmission by components stored > 10 days. The rates of
       transmission for both viruses were similar: 0 to 5 days' storage, 17
       (74%) of 23; 6 to 10 days, 8 (44%) of 18; and 11 to 14, 0 (0%) of 10
       (trend, p = 0.0002). In comparison, 89 percent (112/126) of the
       recipients of anti-HIV-1-positive blood were infected regardless of
       component type, and no effect on transmission occurred with storage for
       < 26 days. CONCLUSION: Transfusion-transmitted HTLV-I and -II are
       similar. The data suggest that a donor's lymphocytes become
       noninfectious when they lose the ability to be activated or to
       proliferate.
 DE    Acquired Immunodeficiency Syndrome/*TRANSMISSION  Blood Component
       Transfusion  *Blood Donors  *Blood Transfusion  Comparative Study  DNA,
       Viral/ANALYSIS  Human  HIV Antibodies/BLOOD  *HIV-1  HTLV-I/GENETICS
       HTLV-I Antibodies/BLOOD  HTLV-I Infections/*TRANSMISSION
       HTLV-II/GENETICS  HTLV-II Antibodies/BLOOD  HTLV-II
       Infections/*TRANSMISSION  Polymerase Chain Reaction  Support, U.S.
       Gov't, P.H.S.  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).