Document 0041
 DOCN  M9480041
 TI    HIV-negative AIDS in Kentucky: a case of idiopathic CD4+ lymphopenia and
       cryptococcal meningitis.
 DT    9410
 AU    Ramirez JA; Srinath L; Ahkee S; Huang AK; Raff MJ; Department of
       Medicine, University of Louisville, School of; Medicine, KY 40292.
 SO    South Med J. 1994 Jul;87(7):751-2. Unique Identifier : AIDSLINE
       MED/94294868
 AB    Here we describe a case of unexplained CD4+ T-lymphocyte depletion and
       cryptococcal meningitis in a patient without evidence of human
       immunodeficiency virus (HIV) infection. This newly recognized syndrome
       has been named idiopathic CD4+ lymphopenia (ICL). When HIV infection is
       suspected in a patient with an opportunistic infection, a CD4+
       lymphocyte count should be obtained, even if the patient's HIV test is
       negative. Patients with persistently low CD4 counts (< 300 cells/microL,
       or < 20%) who show no evidence of HIV infection, who have no defined
       immunodeficiency, and who are not receiving therapy associated with CD4
       depletion have disease that meets the definition of ICL, and the case
       should be reported to the Centers for Disease Control.
 DE    *Acquired Immunodeficiency Syndrome  Adult  Antigens, CD4/*ANALYSIS
       Case Report  Fluconazole/ADMINISTRATION & DOSAGE  Human  *HIV
       Seronegativity  Kentucky/EPIDEMIOLOGY  *Lymphocyte Depletion
       Lymphopenia/EPIDEMIOLOGY/*IMMUNOLOGY  Male  Meningitis,
       Cryptococcal/DRUG THERAPY/EPIDEMIOLOGY/*IMMUNOLOGY  JOURNAL ARTICLE

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