Document 0053
 DOCN  M9480053
 TI    Ability of HIV to promote a TH1 to TH0 shift and to replicate
       preferentially in TH2 and TH0 cells [see comments]
 DT    9410
 AU    Maggi E; Mazzetti M; Ravina A; Annunziato F; de Carli M; Piccinni MP;
       Manetti R; Carbonari M; Pesce AM; del Prete G; et al; Division of
       Clinical Immunology and Allergy, University of; Florence, Italy.
 SO    Science. 1994 Jul 8;265(5169):244-8. Unique Identifier : AIDSLINE
       MED/94294788
 CM    Comment in: Science 1994 Jul 8;265(5169):193-4
 AB    Both interferon gamma (IFN-gamma) produced by T helper 1 (TH1)
       lymphocytes and interleukin-4 (IL-4) produced by TH2 lymphocytes were
       reduced in either bulk circulating mononuclear cells or mitogen-induced
       CD4+ T cell clones from the peripheral blood of individuals infected
       with human immunodeficiency virus (HIV). There was a preferential
       reduction in clones producing IL-4 and IL-5 in the advanced phases of
       infection. However, enhanced proportions of CD4+ T cell clones producing
       both TH1-type and TH2-type cytokines (TH0 clones) were generated from
       either skin-infiltrating T cells that had been activated in vivo or
       peripheral blood T cells stimulated by antigen in vitro when cells were
       isolated from HIV-infected individuals. All TH2 and most TH0 clones
       supported viral replication, although viral replication was not detected
       in any of the TH1 clones infected in vitro with HIV. These results
       suggest that HIV (i) does not induce a definite TH1 to TH2 switch, but
       can favor a shift to the TH0 phenotype in response to recall antigens,
       and (ii) preferentially replicates in CD4+ T cells producing TH2-type
       cytokines (TH2 and TH0).
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Cell Line  Cells,
       Cultured  Human  HIV/*PHYSIOLOGY  HIV
       Infections/*IMMUNOLOGY/MICROBIOLOGY  HIV Seropositivity/IMMUNOLOGY
       Immunologic Memory  Interferon Type II/*BIOSYNTHESIS
       Interleukin-4/BIOSYNTHESIS  Interleukin-5/BIOSYNTHESIS
       Interleukins/*BIOSYNTHESIS  Lymphocyte Transformation  Phenotype
       Support, Non-U.S. Gov't  T-Lymphocytes,
       Helper-Inducer/*IMMUNOLOGY/MICROBIOLOGY  Virus Replication  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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