Document 0077
 DOCN  M9480077
 TI    Intraepithelial lymphocyte subpopulations and dendritic accessory cells
       in normal and hypertrophic adenoids.
 DT    9410
 AU    Bani D; Gallo O; Fini-Storchi O; Department of Human Anatomy and
       Histology, University of; Florence, Italy.
 SO    Laryngoscope. 1994 Jul;104(7):869-73. Unique Identifier : AIDSLINE
       MED/94293745
 AB    The adenoids have been studied by immunocytochemistry and electron
       microscopy in children with and without adenoidal enlargement. Compared
       with normal adenoids, the enlarged ones showed a marked increase in the
       number of intraepithelial gamma-delta TCR+ lymphocytes and a slight
       increase in the number of intraepithelial CD8+ lymphocytes. This was
       accompanied by large amounts of dendritic human lymphocyte antigen (D
       related) (HLA-DR+) S-100+ accessory cells in the lymphoid tissue
       underlying the epithelium. By electron microscopy, dead epithelial cells
       apposed to intraepithelial lymphocytes, and clefts of the epithelial
       lamina, could be seen frequently in the enlarged adenoids, whereas, in
       the normal ones, they could not. Based on these findings, the hypothesis
       is drawn that imbalance of the system of the intraepithelial cytotoxic
       lymphocytes may lead to increased killing of epithelial cells and
       uncontrolled penetration of exogenous agents, and hence be involved in
       the pathogenesis of adenoidal hypertrophy.
 DE    Adenoids/CYTOLOGY/METABOLISM/*PATHOLOGY  Antigens, CD/BIOSYNTHESIS
       Antigens, CD3/BIOSYNTHESIS  Antigens, CD4/BIOSYNTHESIS  Antigens,
       CD8/BIOSYNTHESIS  Antigens, Differentiation, B-Lymphocyte/BIOSYNTHESIS
       B-Lymphocyte Subsets/METABOLISM/*PATHOLOGY  Child  Child, Preschool
       Comparative Study  CD4-CD8 Ratio  Dendritic
       Cells/CYTOLOGY/METABOLISM/PATHOLOGY
       Epithelium/CYTOLOGY/METABOLISM/PATHOLOGY  Human
       Hypertrophy/METABOLISM/PATHOLOGY  HLA-DR Antigens/BIOSYNTHESIS
       Immunohistochemistry  Microscopy, Electron  Nerve Tissue Protein S
       100/BIOSYNTHESIS  Receptors, Antigen, T-Cell, gamma-delta/BIOSYNTHESIS
       T-Lymphocyte Subsets/METABOLISM/*PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).